96017-03-7Relevant academic research and scientific papers
Synthesis and in Vivo Evaluation of [123I]Melanin-Targeted Agents
Roberts, Maxine P.,Nguyen, Vu,Ashford, Mark E.,Berghofer, Paula,Wyatt, Naomi A.,Krause-Heuer, Anwen M.,Pham, Tien Q.,Taylor, Stephen R.,Hogan, Leena,Jiang, Cathy D.,Fraser, Benjamin H.,Lengkeek, Nigel A.,Matesic, Lidia,Gregoire, Marie-Claude,Denoyer, Delphine,Hicks, Rodney J.,Katsifis, Andrew,Greguric, Ivan
supporting information, p. 6214 - 6224 (2015/08/24)
This study reports the synthesis, [123I]radiolabeling, and biological profile of a new series of iodinated compounds for potential translation to the corresponding [131I]radiolabeled compounds for radionuclide therapy of melanoma. Ra
Synthesis and radiosynthesis of a novel PET fluorobenzyl piperazine for melanoma tumour imaging; [18F]MEL054
Taylor, Stephen R.,Roberts, Maxine P.,Wyatt, Naomi A.,Pham, Tien Q.,Stark, Daniela,Bourdier, Thomas,Roselt, Peter,Katsifis, Andrew,Greguric, Ivan
, p. 491 - 499 (2013/07/19)
2-{2-[4-(4-[18F]-Fluorobenzyl)piperazin-1-yl]-2-oxoethyl}isoindolin-1-one ([18F]MEL054), is a new potent indolinone-based melanin binder designed to target melanotic tumours. [18F]MEL054 was prepared by an automated two-step radiosynthesis, comprising of
High-yielding synthesis of 1-isoindolinone derivatives via palladium-catalysed cycloaminocarbonylation
Marosv?lgyi-Haskó, Diána,Takács, Attila,Riedl, Zsuzsanna,Kollár, László
experimental part, p. 1036 - 1040 (2011/03/19)
1-Isoindolinone derivatives were synthesised in high yields (up to 89%) by using 2-iodobenzyl bromide and 2-iodobenzylamine as bifunctional substrates in palladium-catalysed carbonylation. Depending on the N-nucleophiles, two types of compounds were synth
