96108-74-6Relevant academic research and scientific papers
Lipase-catalysed resolution of 1-hydroxyethane-P-phenylphosphinates
Majewska,Kafarski,Lejczak
, p. 561 - 566 (2007/10/03)
Lipase-catalysed hydrolysis and transesterification were used to obtain α-hydroxyalkanephosphinates with two stereogenic centers, namely at α-carbon and phosphorus atoms. These compounds were chosen to check if there is a transfer of chirality from carbon
New syntheses of 1-chloroalkylphosphinates
Morise, Xavier,Savignac, Philippe,Denis, Jean-Marc
, p. 2179 - 2185 (2007/10/03)
Different approaches to the synthesis of 1-chloroalkylphosphinates are described. Initially, we tried to extend a reaction described by Kabachnik for the preparation of chloromethylphosphinic acid chlorides [R1(Cl)P(O)CH2Cl] to C-substituted derivatives. We also considered the possibility of synthesizing the title compounds by routes already described for the formation of diethyl 1-chloroalkylphosphonates. Although these methods have allowed us to obtain several of the desired phosphinates, they suffer from limitations that restrict their synthetic applications. Finally, we have developed a more general approach that allows the formation of a wide range of phosphinates. It involves a selective P-C bond formation by reaction of MeMgCl and PhMgCl with phosphonochloridates, which are prepared by P-chlorination of 1-chloroalkylphosphonates.
A CONVENIENT SYNTHESIS OF O-ETHYL-1-AMINOALKYLPHOSPHINATES
Gajda, Tadeusz
, p. 59 - 64 (2007/10/02)
1-Aminoalkylphosphinates 4 have been obtained in good yields in a one-step transformation by the Mitsunobu reaction of 1-hydroxyalkylphosphinates 1 with hydrazoic acid, and subsequent treatment of the intermediate azides 2, with triphenylphosphine, follow
