96372-25-7

Upstream product

• 141-97-9 ethyl acetoacetate 
• 100-63-0 phenylhydrazine 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 89-25-8 edaravone 

Downstream Products

• 25111-96-0 4-(4-(dimethylamino)benzylidene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one 

Relevant academic research and scientific papers

Synthesis and characterization of two novel biological-based nano organo solid acids with urea moiety and their catalytic applications in the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol), coumarin-3-carboxylic acid and cinnamic acid derivatives under mild and green conditions

2-Carbamoylhydrazine-1-sulfonic acid and carbamoylsulfamic acid as novel, mild and biological-based nano organocatalysts with urea moiety were designed, synthesized and fully characterized by FT-IR, 1H NMR, 13C NMR, mass spectrometry, elemental analysis, thermal gravimetric, derivative thermal gravimetric, X-ray diffraction patterns, scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, atomic force microscopy and UV/Vis analysis. The catalytic applications of 2-carbamoylhydrazine-1-sulfonic acid and carbamoylsulfamic acid were studied in the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol), coumarin-3-carboxylic acid and cinnamic acid derivatives via the condensation reaction between several aromatic aldehydes and 1-phenyl-3-methylpyrazol-5-one (synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols)), the Knoevenagel condensation of Meldrum's acid with salicylaldehyde derivatives (synthesis of coumarin-3-carboxylic acids) and the condensation of Meldrum's acid with aromatic aldehydes (synthesis of cinnamic acids) under mild and solvent-free conditions. In the presented studies, some products were formed and reported for the first time. The described nano organo solid acids have potential in industry.

Synthesis of sulfonated melamine-functionalized Fe3O4@SiO2@Si–(CH2)3@melamine nanoparticles and its application in the synthesis of 4,4’-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)s and hexahydroqui

In this work, sulfonated melamine-functionalized Fe3O4@SiO2@Si-(CH2)3@melamine nanoparticles were prepared through a simple approach and characterized by energy dispersive X-ray analysis (EDX), field

Synthesis and evaluation of biological activities of bis(Spiropyrazolone)cyclopropanes: A potential application against Leishmaniasis

This work focuses on the search and development of drugs that may become new alternatives to the commercial drugs currently available for treatment of leishmaniasis. We have designed and synthesized 12 derivatives of bis(spiropyrazolone)cyclopropanes. We

An Organocatalyzed Efficient One-pot Synthesis, Biological Evaluation, and Molecular Docking Studies of 4,4′-(Arylmethylene)bis-(3-methyl-1-phenyl-1H-pyrazol-5-ols)

The synthesis of 4,4′-(arylmethylene)bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol) derivatives catalyzed by ?-proline is a simple, versatile, and efficient method. In vitro antioxidant, anti-inflammatory, and antimicrobial activities of compounds 4a, 4b, 4c, 4d

Application of a biological-based nanomagnetic catalyst in the synthesis of bis-pyrazols and pyrano[3,2-c]pyrazoles

{Fe3O4@SiO2@(CH2)3-thiourea dioxide-SO3H/HCl}, a newly reported nanomagnetic core–shell supported solid acid catalyst, was successfully employed in the preparation of 4,4′-(arylmethylene)bi

Stability Constant for Thorium (IV) Complexes with Arylbis-(5-Hydroxy-3-methyl-1-phenyl-4-pyrazolyl)- Methane Ligands

Chelate stability constants of arylbis(5-hydroxy-3-methyl-1-phenyl-4-pyrazolyl)methane derivatives with thorium(IV) ion were determined by the potentiometric method at 30 deg C and 0.1 mol dm-3 (KNO3) in 75percent (v/v) dioxane-water sol

Stability Constants of Thorium(IV) Complexes with Aryl-bis-(5-hydroxy-3-methyl-1-phenyl-4-pyrazolyl) Methane Ligands

Stability constants of complexes of aryl-bis-(5-hydroxy-3-methyl-1-phenyl-4-pyrazolyl)methane derivatives with thorium(IV) ions were determined by the potentiometric method at 30 deg C and an ionic strength of 0.1 mol*dm-3 (KNO3) in 75

YTTRIUM AND LANTHANIDE CHELATES OF ARYLBIS (5-HYDROXY-3-METHYL-1-PHENYL-4-PYRAZOLYL)METHANE

Chelate stability constants of arylbis(5-hydroxy-3-methyl-1-phenyl-4-pyrazolyl) methane ligands (H2ArBPyM) with yttrium and some lanthanide ions (M3+) were determined by potentiometric method at 30 deg C and at an ionic strength of 0.1 with pot

EFFECT OF SUBSTITUENTS ON THE PROTONATION CONSTANTS OF SOME BIS(PHENYLPYRAZOLYL)METHANE LIGANDS

The acid dissociation constants (pKH) of a series (I to XVI) of substituted-bis(phenylpyrazolyl)methane compounds have been determined potentiometrically in 75percent (v/v) dioxane-water at 30 deg C and 0.1 M ionic strength.The tautomerism of t