5616-32-0

Basic information

• Product Name: METHYLAMINOACETONITRILE
• Synonyms: (methylamino)-acetonitril;(N-methylamino)acetonitrile;Acetonitrile, (methylamino)-;Acetonitrile,(methylamino)-;Glycinonitrile, N-methyl-;N-Methylaminoacetonitrile;Sarcosinonitrile;METHYLAMINOACETONITRILE
• CAS NO: 5616-32-0
• Molecular Formula: C₃H₆N₂
• Molecular Weight: 70.09
• EINECS: 227-037-7
• Product Categories: Small molecule
• Mol File: 5616-32-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 65 °C / 20mmHg
• Flash Point: 44 °C
• Appearance: /
• Density: 0,92 g/cm3
• Refractive Index: 1.4190 to 1.4220
• Storage Temp.: Freezer
• PKA: 4.74±0.10(Predicted)
• CAS DataBase Reference: METHYLAMINOACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYLAMINOACETONITRILE(5616-32-0)
• EPA Substance Registry System: METHYLAMINOACETONITRILE(5616-32-0)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-20/21/22-38-36-22-10
• Safety Statements: 16-23-36/37/39
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 5616-32-0(Hazardous Substances Data)

Usage

General Description

Methylaminoacetonitrile is an organic compound with the chemical formula C3H6N2. It is a colorless liquid that is used primarily in the production of pharmaceuticals, agrochemicals, and other organic compounds. Methylaminoacetonitrile is a versatile building block in organic synthesis, frequently used in the manufacture of a wide range of chemical products. It is also utilized in the preparation of various intermediates for pharmaceuticals and agricultural chemicals. Additionally, it is an important starting material for the synthesis of various heterocyclic compounds and is widely utilized in the field of organic chemistry as a versatile reagent for the preparation of a variety of nitrogen-containing compounds. Methylaminoacetonitrile can also be used as a solvent in various chemical reactions.

InChI:InChI=1/C3H6N2/c1-5-3-2-4/h5H,3H2,1H3

Upstream product

• 107-16-4 glycolonitrile 
• 74-89-5 methylamine 
• 50-00-0 formaldehyd 
• 593-51-1 methylamine hydrochloride 
• 7732-18-5 water 
• 74-90-8 hydrogen cyanide 
• 773837-37-9 sodium cyanide 
• 590-17-0 cyanomethyl bromide 
• 143-33-9 sodium cyanide 
• 7647-01-0 hydrogenchloride 
• 151-50-8 potassium cyanide 
• 108-74-7 1,3,5-trimethyl-1,3,5-triazacyclohexane 
• 59264-17-4 N-(methylimino)acetonitrile 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 1801-62-3 1,3-dimethyl-2-thioxoimidazolidin-4-one 
• 89244-30-4 N-Cyanomethyl-4,N-dimethyl-benzamide 
• 180976-09-4 cyanomethyl-methyl-carbamic acid tert-butyl ester 
• 97-78-9 N-acyl sarcosinate 
• 52558-73-3 N-tetradecanoylsarcosine 
• 4316-73-8 sodium sarcosinate 
• 137537-40-7 2-Benzoyl-N-cyanomethyl-N-methyl-benzamide 
• 1449664-91-8 N-(cyanomethyl)-4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-N-methyl-5,6-dihydropyridine-1(2H)-carboxamide 
• 1404505-44-7 2-(4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-1-yl)-N-(cyanomethyl)-N-methylacetamide 

Relevant articles and documents

High-yielding automated convergent synthesis of no-carrier-added [11C-carbonyl]-labeled amino acids using the strecker reaction

A new variant of the Strecker synthesis using no-carrier-added [11C]cyanide for the synthesis of radiolabeled amino acids is described. The protocol is fully automated using a radiochemistry synthesis module and applied to the production of a number of new PET radiotracers. [11C-Carbonyl]sarcosine, [11C-carbonyl]methionine, [11C-carbonyl]-N-phenylglycine, and [11C-carbonyl]glycine are all synthesized in moderate to good radiochemical yields. The synthesis of [11C-carbon-yl]sarcosine has been validated for production of doses for clinical use, and preliminary evaluation of the new radiotracer in PC3 tumor-bearing mice is also reported.

Microwave-assisted solvent-free intramolecular 1,3-dipolar cycloaddition reactions leading to hexahydrochromeno[4,3-b]pyrroles: scope and limitations

We report the microwave-assisted solvent-free synthesis of hexahydrochromeno[4,3-b]pyrroles. Intramolecular 1,3-dipolar cycloadditions proceed under these conditions within 15-40 min in 16-84% yields. An influence of the microwave irradiation upon various [3+2] cycloaddition reaction intermediates was studied. Additionally, a scope and limitations of these reactions including an influence of the dipolarophile geometry upon the cycloaddition selectivity and steric demands of the dipole upon its reactivity were also disclosed. These observations led us to postulate a preferable transition state of the reaction. Finally, an influence of the microwave irradiation to the isomerization of activated olefins was also described.

TiCl4 induced N-methyleneamine equivalents: A new route to aminoacetonitriles

TiCl4 induced N-methyleneamine equivalents from hexahydro-1,3,5-triazines or N-(methoxymethyl)amines were reacted with trimethylsilyl cyanide to give aminoacetonitriles in 40-90% yield.