97906-41-7

Upstream product

• 5927-18-4 trimethyl phosphonoacetate 
• 97855-75-9 (1S,2S)-1,3,3-Trimethyl-2-[2-(2-oxo-cyclohex-3-enyl)-ethyl]-cyclohexanecarbaldehyde 
• 110715-81-6 (+)-(1S,4aS,8aS)-1,2,3,4,4a,5,6,7,8,8a-decahydro-5,5,8a-trimethylnaphthalen-1-ol 
• 108-94-1 cyclohexanone 
• 110715-82-7 (-)-(1''S,2''S)-(E)-2-<2'-<2''-(dioxolan-2-yl)-2'',6'',6''-trimethylcyclohexyl>ethylidene>cyclohexanone 
• 110654-75-6 (+)-(4aS,5S)-5-benzoyloxy-3,4,4a,5,6,7-hexahydro-1,1,4a-trimethylnaphthalen-2(1H)-one 
• 90122-63-7 (+/-)-(1''RS,2''RS)-6-<2-<3-hydroxyprop-1(E)-enyl>-2'',6'',6''-trimethylcyclohexylethyl>cyclohex-2-enone 
• 90122-62-6 (+/-)-(1'RS,2'RS)-3-<2'-<2-(2-methoxyphenyl)ethyl>-1',3',3'-trimethylcyxclohexyl>prop-2(E)-enol 
• 110654-74-5 ethyl (+/-)-(1'RS,2'RS)-3-<-2'-<2-(2-methoxyphenyl)ethyl>-1',3',3'-trimethylcyclohexyl>prop-2(E)-enoate 
• 92830-64-3 (+/-)-(1'RS,2'RS)-(E)-3-<1',3',3'-trimethyl-2'-<2-(2-oxocyclohex-3-enyl)ethyl>cyclohexyl>acrylaldehyde 
• 90122-60-4 (+/-)-(1RS,2SR)-2-<2-(2-methoxyphenyl)-ethyl>-1,3,3-trimethyl-5-oxocyclohexanecarbonitrile 
• 110654-72-3 (+/-)-(1RS,2SR)-5,5-ethylenedithio-2-<2-(2-methoxyphenyl)ethyl>-1,3,3-trimethylcyclohexanecarbaldehyde 
• 110654-71-2 (+/-)-(1RS,2SR)-5,5-ethylenedithio-2-<2-(2-methoxyphenyl)ethyl>-1,3,3-trimethylcyclohexanecarbonitrile 
• 90122-61-5 (+/-)-(1RS,2SR)-2-<2-(2-methoxyphenyl)ethyl>-1,3,3-trimethylcyclohexanecarbaldehyde 

Downstream Products

• 7721-78-0 (+)-atisirene 

Relevant academic research and scientific papers

An Enantioselective Total Synthesis of (+)-Atisirene by Intramolecular Double Michael Reaction

1,6-Conjugate addition of 2-methoxybenzylmagnesium bromide to 4-methylene-3,5,5-trimethylcyclohex-2-enone (7), followed by hydrocyanation, gave (+/-)-(1RS,2SR)-2--1,3,3-trimethyl-5-oxocyclohexanecarbonitrile (9), which was conver

INTRAMOLECULAR DOUBLE MICHAEL REACTION III, STEREOSELECTIVE CHIRAL SYNTHESIS OF ATISIRAN-15-ONE

Atisiran-15-one (5) was stereoselectively synthesized starting from the ketone (10) through the intramolecular double Michael reaction.

INTRAMOLECULAR DOUBLE MICHAEL REACTION. PART II. SYNTHESIS OF ISOATISIRENE TYPE COMPOUND

Intramolecular double Michael reaction of the α,β-unsaturated enone ester (16), prepared from the dienone (5), stereoselectively gave the tetracyclic product (17), which was converted into the isoatisirene type compound (20).