97971-74-9

Basic information

• Product Name: Methanone, [5-(benzoyloxy)-2-hydroxyphenyl]phenyl-
• Synonyms: 5-Benzoyloxy-2-hydroxy-benzophenon;Methanone,[5-(benzoyloxy)-2-hydroxyphenyl]phenyl;2-benzoyl-4-benzoyloxy phenol;5-benzoyloxy-2-hydroxy-benzophenone
• CAS NO: 97971-74-9
• Molecular Formula: C20H14O4
• Molecular Weight: 318.329
• Mol File: 97971-74-9.mol

Chemical Properties

• Melting Point: 213–214°C
• Boiling Point: 486.6±35.0 °C(Predicted)
• Density: 1.276±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Methanone, [5-(benzoyloxy)-2-hydroxyphenyl]phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [5-(benzoyloxy)-2-hydroxyphenyl]phenyl-(97971-74-9)
• EPA Substance Registry System: Methanone, [5-(benzoyloxy)-2-hydroxyphenyl]phenyl-(97971-74-9)

Safety Data

• Hazardous Substances Data: 97971-74-9(Hazardous Substances Data)

Usage

Preparation

Obtained by Fries rearrangement, ? of quinol monobenzoate in the presence of aluminium chloride (3.3 mol) at 140° for 1 h (14%); ? of quinol dibenzoate in the presence of aluminium chloride (2 mol) at 190– 200° for 1.5 h or (3.3 mol or 5.5 mol of catalyst) at 140° for 1 h (33%); ? of p-methoxyphenyl benzoate in the presence of aluminium chloride (3.3 mol) at 130–132° for 1 h or at 150–155° for 1 h (<9%).

Upstream product

• 14210-97-0 1,4-dibenzoyloxybenzene 
• 7446-70-0 aluminium trichloride 
• 2444-19-1 4-hydroxyphenyl benzoate 
• 98-88-4 benzoyl chloride 
• 150-78-7 1,4-dimethoxybezene 

Downstream Products

• 4038-13-5 2,5-dimethoxybenzophenone 
• 2050-37-5 2,5-dihydroxybenzophenone 

Relevant articles and documents

2-(2,2-DIARYLETHYL)-CYCLIC AMINE DERIVATIVE OR SALT, SYNTHESIS THEREOF, AND APPLICATION AND COMPOSITION THEREOF

The disclosure relates to a 2-(2,2-diarylethyl)-cyclic amine derivative or salt, a synthesis method, an application and a composition thereof. Biological activity test shows that this kind of 2-(2,2-diarylethyl)-cyclic amine derivative has good M-receptor antagonistic activity; and can be used as an active component of drugs for the treatment of the diseases mediated or regulated by muscarinic receptors, such as asthma, chronic obstructive pulmonary disease (COPD), overactive bladder (OAB), bronchospasm with chronic obstructive pulmonary disease, visceral spasm, irritable bowel syndrome, Parkinson's disease, depression or anxiety, schizophrenia and related mental diseases.

Diaryl vinyl cyclic amine derivatives and preparation method thereof

The invention provides diaryl vinyl cyclic amine derivatives and a preparation method thereof. The aryl substituted groups of the diaryl vinyl cyclic amine derivatives have a hydroxyl or hydroxy derivative functional groups in the ortho positions of vinyl groups. The bioactivity test shows that the compounds have anticholinergic activity, and the ortho-hydroxy groups can significantly enhance theantagonistic activity; the compounds can be used as active pharmaceutical ingredients for treating asthma, chronic obstructive pulmonary disease (COPD), rhinorrhea caused by allergic rhinitis and cold, urinary incontinence, Parkinson's disease, and the like.

Facile synthesis of regio-isomeric naphthofurans and benzodifurans

Naphtho[1,2-b]furans 1a-f, naphtho[2,1-b]furans 2a-f, benzo[1,2-b:5,4- b′]difurans 3a-b, benzo[1,2-b:4,5-b′]difurans 4a-b, and benzo[1,2-b:4,3-b′]difurans 5a-b were synthesized by base-catalyzed cyclization reaction of the corresponding o-alkoxybenzoylarene derivatives. The o-alkoxybenzoylarenes were obtained from the etherification reaction of the o-hydroxybenzoylarenes, which were prepared either by the reaction of methoxyarenes with benzoyl chloride in the presence of aluminum chloride or by photo-Fries rearrangement of aryl benzoates. Graphical Abstract.

Photo-Fries Rearrangement: Rearrangement of Benzoyloxy Compounds

Photo-Fries migration of the benzoyl group in 1-benzoyloxy-5-methoxy naphthalene, 1,4-dibenzoyloxy-2-methyl naphthalene, 1,4-dibenzoyloxy naphthalene, 1,5-dibenzoyloxy naphthalene, 8-benzoyloxy quinoline, 1,2-dibenzoyloxy benzene, 1,3-dibenzoyloxy benzene, and 1,4-dibenzoyloxy benzene afforded the corresponding mono and di-C-benzoyl products. - Keywords: Naphthyl benzoate derivatives; 8-Benzoyloxy quinoline; Phenyl dibenzoates