2050-37-5

Basic information

• Product Name: 2,5-Dihydroxybenzophenone
• Synonyms: 2,5-Dihydroxybenzophenone
• CAS NO: 2050-37-5
• Molecular Formula: C₁₃H₁₀O₃
• Molecular Weight: 214.2167
• Mol File: 2050-37-5.mol
• Article Data: 17

Chemical Properties

• Melting Point: 125–126°C
• Boiling Point: 401.5°Cat760mmHg
• Flash Point: 210.8°C
• Appearance: /
• Density: 1.302g/cm³
• Vapor Pressure: 5.07E-07mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 2,5-Dihydroxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dihydroxybenzophenone(2050-37-5)
• EPA Substance Registry System: 2,5-Dihydroxybenzophenone(2050-37-5)

Safety Data

• Hazardous Substances Data: 2050-37-5(Hazardous Substances Data)

Usage

Preparation

Preparation by Fries rearrangement of hydroquinone dibenzoate with aluminium chloride, at 140° for 1 h (33%); at 190–200° for 1 h 30 min (50%) or at 200° for 20 min.

InChI:InChI=1/C13H10O3/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8,14-15H

Upstream product

• 123-31-9 hydroquinone 
• 65-85-0 benzoic acid 
• 108-73-6 3,5-dihydroxyphenol 
• 14210-97-0 1,4-dibenzoyloxybenzene 
• 98-88-4 benzoyl chloride 
• 97971-74-9 (2-hydroxy-5-benzoyloxyphenyl)(phenyl)methanone 
• 100-52-7 benzaldehyde 
• 106-51-4 p-benzoquinone 
• 108-95-2 phenol 
• 135-19-3 β-naphthol 
• 7446-70-0 aluminium trichloride 
• 93-99-2 benzoic acid phenyl ester 
• 611-73-4 Benzoylformic acid 
• 4038-13-5 2,5-dimethoxybenzophenone 

Downstream Products

• 96700-25-3 Acetic acid 2-oxo-3,4-diphenyl-2H-chromen-6-yl ester 
• 420782-25-8 ethyl 3-phenyl-4,7-dioxo-4,7-dihydrobenzo[b]thiophene-2-carboxylate 
• 40547-03-3 6-Methoxy-4-phenyl-2H-1-benzopyran-2-one 
• 55548-96-4 6-hydroxy-4-phenyl-chromen-2-one 
• 320576-76-9 6-ethoxy-4-phenyl-2H-chromen-2-one 
• 137058-43-6 3-Phenyl-5-phenylamino-benzo[c]isoxazole-4,7-dione 
• 79521-10-1 5,5'-[2-(hydroxyphenylmethyl)-1,4-phenylenebis(oxy)]bis[2,2-dimethylpentanoic acid] 
• 96700-26-4 Acetic acid 5-(2,3-dibromo-propyl)-2-oxo-3,4-diphenyl-2H-chromen-6-yl ester 
• 96700-17-3 Acetic acid 5-allyl-2-oxo-3,4-diphenyl-2H-chromen-6-yl ester 
• 96700-10-6 5-Allyl-6-hydroxy-3,4-diphenylcoumarin 
• 96700-09-3 6-Allyloxy-3,4-diphenylcoumarin 
• 96700-08-2 6-Hydroxy-3,4-diphenylcoumarin 

Relevant articles and documents

2-(2,2-DIARYLETHYL)-CYCLIC AMINE DERIVATIVE OR SALT, SYNTHESIS THEREOF, AND APPLICATION AND COMPOSITION THEREOF

The disclosure relates to a 2-(2,2-diarylethyl)-cyclic amine derivative or salt, a synthesis method, an application and a composition thereof. Biological activity test shows that this kind of 2-(2,2-diarylethyl)-cyclic amine derivative has good M-receptor antagonistic activity; and can be used as an active component of drugs for the treatment of the diseases mediated or regulated by muscarinic receptors, such as asthma, chronic obstructive pulmonary disease (COPD), overactive bladder (OAB), bronchospasm with chronic obstructive pulmonary disease, visceral spasm, irritable bowel syndrome, Parkinson's disease, depression or anxiety, schizophrenia and related mental diseases.

Efficient microwave-assisted direct C-benzoylation of phenols and naphthols with benzoic acid catalyzed by bismuth triflate under solvent-free or ionic liquid conditions

An efficient and simple route for the synthesis of ortho-hydroxyaryl ketones has been developed. The microwave-assisted direct C-benzoylation of phenols and naphthols in the presence of metal triflates afforded the corresponding ortho-hydroxyaryl ketones in moderate to excellent yields. Bismuth triflate showed the best catalytic performance compared to other metal triflates. The protocol has advantages including short reaction times, high chemoselectivity towards C-acylation, and simple work-up. Additionally, bismuth triflate can be easily recovered and reused several times without significant loss of catalytic performance.

Eco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones

A broad variety of oxygen-substituted diaryl ketones has been synthesized by solar energy-induced Friedel Crafts acylations of 1,4-benzo- and 1,4-naphthoquinones with benzaldehydes. The in vitro antiproliferative properties of the photoproducts were asses