98153-12-9

Upstream product

• 16619-68-4 1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one 
• 16619-66-2 1-(2-methoxyphenyl)-3-phenylprop-2-yn-1-one 
• 135-02-4 ortho-anisaldehyde 
• 1214-47-7 1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 90-02-8 salicylaldehyde 
• 98-88-4 benzoyl chloride 
• 4010-33-7 2-acetylphenyl benzoate 
• 536-74-3 phenylacetylene 
• 16619-51-5 2'-allyloxychalcone 
• 17317-75-8 3-benzylamino-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 
• 5453-03-2 2-phenyl-3-benzoyl-4H-1-benzopyran-4-one 
• 100-52-7 benzaldehyde 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 1431842-00-0 ethyl 2,2-difluoro-2-(4-oxo-2-phenyl-4H-chromen-3-yl)-acetate 
• 1839-72-1 2-phenylbenzofuran 
• 525-82-6 FLAVONE 
• 1234675-39-8 11-((2,6-diisopropylphenyl)imino)indeno[1,2-b]chromen-10(11H)-one 
• 6880-06-4 3,3''-biflavone 

Relevant academic research and scientific papers

Iodine-mediated direct synthesis of 3-iodoflavones

Molecular iodine has been used for the regioselective, one pot, direct synthesis of 3-iodoflavones from 2′-allyloxy chalcones, 2′-hydroxy chalcones and flavones. Allyl deprotection, cyclization dehydrogenation and α-iodination of 2′-allyloxychalcones has been achieved in a single step to offer 3-iodoflavones.

Heterocyclic Iodoniums for the Assembly of Oxygen-Bridged Polycyclic Heteroarenes with Water as the Oxygen Source

A diverse set of novel heterocyclic iodoniums was synthesized for the first time. The reactions of these unique iodoniums with environmentally benign water as the oxygen source provided structurally complex oxygen-incorporated heteropolycycles that are essential motifs in natural products and biologically active compounds. The transformation only required low-cost copper acetate. Further derivatization of the obtained polycycles expanded the structural diversity, which is important in the building of chemical libraries for drug discovery.

Hypervalent iodine compound containing heterocyclic ring as well as preparation method and application thereof

The invention discloses a hypervalent iodine compound containing a heterocyclic ring as well as a preparation method and application thereof. A structure of the compound is shown as a formula (I): theformula (I) is shown in the description, wherein R is selected from hydrogen, halogen, alkyl, alkoxy, halogenated alkyl, halogenated alkoxy, nitryl, cyano, hydroxyl or -COOR'; R' is alkyl or halogenated alkyl; and Het is substituted or non-substituted 1,4-benzopyranone, substituted or non-substituted quinolone, substituted or non-substituted isoquinoline, substituted or non-substituted thiobenzopyranone, substituted or non-substituted coumarin and substituted or non-substituted oxepin. The compound disclosed by the invention is novel in structure and is the hypervalent iodine compound containing the heterocyclic ring; the hypervalent iodine compound is stable in structure and simple in preparation method; and meanwhile, the hypervalent iodine compound has a very good inhibition effect onML-1 and MOLM-13 cells and has an extremely great application prospect on prevention and/or treatment effect on leukemia.

Photo-induced tandem cyclization of 3-iodoflavones with electron rich five-membered heteroarenes

Vinyl radicals were generated from 3-iodoflavones under a mercury lamp and tandem cyclization reactions occurred with five-membered heteroarenes entailing two consecutive C-C bond formations to synthesize benzo[e]chromeno[2,3-g]indol-13(1H)-one derivatives. The tandem cyclization reactions worked in acetonitrile without any additives such as transition metals, ligands and oxidants, giving rise to a broad variety of novel polycyclic xanthone frameworks in good yield under mild and environmentally friendly reaction conditions.

New gas-phase domino processes leading to benzopyranones and benzofurans

A new domino approach to flavones by gas phase pyrolysis of β,γ-dioxophosphonium ylides containing a 2-methoxyphenyl group is frustrated by unexpected and novel decarbonylation of the intermediate flavon-3-yl radical leading to 2-phenylbenzofuran. Alternative approaches based on dioxolane protection of one carbonyl, or selective elimination in β,β′-dioxo or β-oxo-β′-thioxo ylides were not successful, but pyrolysis of a β-oxo-β′-phenylimino ylide did give the required domino reaction leading to a protected benzopyranone in moderate yield.

Cobalt-Catalyzed Annulation of Salicylaldehydes and Alkynes to Form Chromones and 4-Chromanones

A unique cobalt(I)-diphosphine catalytic system has been identified for the coupling of salicylaldehyde (SA) and an internal alkyne affording a dehydrogenative annulation product (chromone) or a reductive annulation product (4-chromanone) depending on the alkyne substituents. Distinct from related rhodium(I)- and rhodium(III)-catalyzed reactions of SA and alkynes, these annulation reactions feature aldehyde C-H oxidative addition of SA and subsequent hydrometalation of the C=O bond of another SA molecule as common key steps. The reductive annulation to 4-chromanones also involves the action of Zn as a stoichiometric reductant. In addition to these mechanistic features, the CoI catalysis described herein is complementary to the RhI- and RhIII-catalyzed reactions of SA and internal alkynes, particularly in the context of chromone synthesis.

Synthesis of 2-substituted 3-iodo-4H-chromen-4-ones

3-Iodochromones containing phenyl and furyl fragments at position 2 were synthesized by heterocyclization of β-ketoenamines.

Synthesis and antifungal activities of natural and synthetic biflavonoids

The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol and Ullmann condensations. Some of these compounds, especially bichalcones, display an interesting activity against fungi, higher than that of the corresponding monomers.

Copper-free Sonogashira coupling of acid chlorides with terminal alkynes in the presence of a reusable palladium catalyst: An improved synthesis of 3-iodochromenones (= 3-iodo-4H-1-benzopyran-4-ones)

Pd/C is used as an efficient catalyst for the copper-free Sonogashira coupling of acid chlorides and terminal alkynes to afford ynones in high yields (Tables 1 and 3). Cyclization of (2-methoxyaryl)-substituted ynones induced by I2/ammonium cer

Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates

Different flavone-, indole-, and furan-17β-estradiol conjugates, linked via alkyl spacer chains extending from the 17α-position of the estradiol moiety, were synthesized by Pd-catalyzed cross-coupling reactions. Structures were assigned based on spectrosc