98192-57-5Relevant articles and documents
Neoflavonoids as inhibitors of HIV-1 replication by targeting the Tat and NF-κB pathways
Olmedo, Dionisio A.,López-Pérez, José Luis,Del Olmo, Esther,Bedoya, Luis M.,Sancho, Rocío,Alcamí, José,Mu?oz, Eduardo,San Feliciano, Arturo,Gupta, Mahabir P.
, (2017/03/08)
Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were teste
Synthesis of Mammea Coumarins. Part 1. The Coumarins of the Mammea A, B, and C Series
Crombie, Leslie,Jones, Raymond C. F.,Palmer, Christopher J.
, p. 317 - 332 (2007/10/02)
The naturally-occuring Mammea coumarins of the 4-phenyl-(mammea A), propyl-(mammea B), and 4-pentyl-(mammea C) series have been prepared by Pechmann condensation of an acylphloroglucinol (3-methylbutyryl-, 2-methylbutyryl-, butyryl-, or 2-methylpropionyl-) with the appropriate β-ketoester to give a mixture of 6- and 8-acyl-5,7-dihydroxycoumarins that could be separated.C-Alkylation with 3-methylbut-2-enyl bromide, or 3,7-dimethylocta-2,6-dienyl chloride, in aqueous potassium hydroxide completed the synthesis of the Mammea coumarins having unmodified prenyl or geranyl substituents; oxidative modification of the prenyl group led to the mammea cyclo E and cyclo F coumarins.Some mammea cyclo D (chromeno) coumarins were synthesized by reaction of acylcoumarins with 1,1-dimethoxy-3-methylbutan-3-ol.
