98361-28-5

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 1121-18-2 2-methyl-2-cyclohexen-1-one 
• 75-16-1 methylmagnesium bromide 
• 1502-24-5 2,3-dimethylcyclohexan-1-ol 
• 13395-76-1 2,3-dimethylcyclohexanone 

Downstream Products

• 98361-31-0 cis-2,3-Dimethyl-2-(3-oxobutyl)cyclohexanone 
• 39257-08-4 trimethyl-1-cyclohexanone 
• 93777-43-6 4,4a,5,6,7,8-hexahydro-4a,5-dimethyl-2(3H)-naphthalenone 
• 127717-10-6 (2SR,3SR)-2,3-dimethyl-2-ethenylcyclohexanone 
• 127717-10-6 (2RS,3SR)-2,3-dimethyl-2-ethenylcyclohexanone 
• 98361-31-0 2,3-Dimethyl-2-(3-oxobutyl)cyclohexanone 

Relevant academic research and scientific papers

Total synthesis of five natural eremophilane-type sesquiterpenoids

The first total syntheses of five natural eremophilane-type sesquiterpenoids were achieved in 4-12 steps via a common synthetic intermediate. The syntheses feature a double Michael addition, Robinson annulation, α-enolization of an unsaturated ketone, and

Total syntheses of anominine and tubingensin A

A divergent strategy for the total syntheses of the indole terpenoid anominine (1) and its natural congener tubingensin A (2) has been developed. The common intermediate 11 bearing all of the required stereogenic centers for both natural products was first assembled by employing a Ueno-Stork radical cyclization and a Sc(OTf)3-mediated Mukaiyama aldol reaction to form the key C-C bonds in a stereocontrolled manner. The route to anominine features a radical deoxygenation followed by an efficient side-chain installation, while the path to tubingensin A exploits a CuOTf-promoted 6π-electrocyclization/ aromatization sequence to forge the central region of the pentacyclic scaffold.

Access to 1,2-diketones by an unusual radical cascade

An unusual radical fragmentation of an unstrained cyclohexane structure was observed leading to complex 1,2-diketones.

First total synthesis of (±)-stachyflin

We achieved the first total synthesis of (±)-stachyflin in 29 steps, including the construction of cis-fused decalin and the formation of an etheral bond at its bridgehead as key transformations.

Lewis Acid Catalysed Michael-type Addition. A New Regio- and Diastereoselective Annulation Method using Methyl Vinyl Ketone

A new annulation method is presented, involving a boron trifluoride catalysed Michael addition of trialkylsilyl enol ethers to methyl vinyl ketone (MVK) in the presence of a hydroxylic compound.This methodology allows regiospecific 3-oxobutylation of eith