98769-82-5 Usage
General Description
Reboxetine Methanesulfonate is a pharmaceutical compound used for the treatment of depression and attention-deficit hyperactivity disorder (ADHD). It is a selective norepinephrine reuptake inhibitor (NRI) that works by increasing the levels of norepinephrine in the brain, which helps regulate mood and attention. The methanesulfonate salt form of reboxetine is water-soluble, making it easier to administer and absorb in the body. It has been approved for use in several countries and is considered an effective option for individuals who do not respond well to other types of antidepressants or ADHD medications. Like all medications, it should be used under the guidance of a healthcare professional and may have potential side effects and contraindications that need to be considered.
Check Digit Verification of cas no
The CAS Registry Mumber 98769-82-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,7,6 and 9 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 98769-82:
(7*9)+(6*8)+(5*7)+(4*6)+(3*9)+(2*8)+(1*2)=215
215 % 10 = 5
So 98769-82-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m0./s1
98769-82-5Relevant articles and documents
The use of environmental metrics to evaluate green chemistry improvements to the synthesis of (S,S)-reboxetine succinate
Assaf, Georges,Checksfield, Graham,Critcher, Doug,Dunn, Peter J.,Field, Stuart,Harris, Laurence J.,Howard, Roger M.,Scotney, Gemma,Scott, Adam,Mathew, Suju,Walker, Geoffrey M. H.,Wilder, Alexander
, p. 123 - 129 (2012/04/11)
The Pfizer Green Chemistry metrics program is described and exemplified with a case history involving the synthesis of (S,S)-reboxetine succinate. The initial route used a classical resolution approach and generated high levels of waste. This route was replaced by an enantiospecific synthesis which used Sharpless epoxidation chemistry, an enzymatic process to selectively protect a primary alcohol and a new efficient method of chiral morpholine construction as key steps. These improvements reduced the levels of waste produced by the synthesis by more than 90%. Detailed metrics starting from a common starting material (trans-cinnamyl alcohol) for all routes of synthesis are presented.
Configurational studies on 2-[α-(2-ethoxyphenoxy)benzyl]morpholine FCE 20124
Melloni,Della Torre,Lazzari,et al.
, p. 1393 - 1399 (2007/10/02)
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