98935-66-1Relevant academic research and scientific papers
Synthesis of an Optically Active Octahydro-2H-pyridopyrazine Based CNS Agent
Urban, Frank J.,Breitenbach, Ralph,Murtiashaw, Charles W.,Vanderplas, Brian C.
, p. 321 - 324 (1995)
A synthesis of an optically active octahydro-2H-pyridopyrazine is presented.The key sequence involved the equilibration of an optically active cis-aldehyde to give the thermodynamic transaldehyde that was trapped by nitromethane anion.
Preparation of differentiated diamides of 4,5,6,7-tetrahydropyrazolo[1,5-a] pyridine-2,6- and -3,6-dicarboxylic acids suitable for parallel synthesis
Erdmane,Zemribo
scheme or table, p. 811 - 816 (2012/03/22)
1,3-Dipolar cycloaddition of a bicyclic sydnone to a propargylic acid amide affords 4,5,6,7-tetra-hydropyrazolo[1,5-a]pyridine-2,6- and -3,6-dicarboxylic acid monoamides which are further converted to corresponding differentiated diamides.
Synthesis of trans-7-Hydroxymethyl-2-(2-benzisoxazol-3-yl)octahydro-2H-pyridopyrazine
Urban, Frank J.
, p. 857 - 862 (2007/10/02)
An efficient synthesis of trans-7-hydroxymethyl-2-(2-benzisoxazol-3-yl)octahydro-2H-pyridopyrazine 2 is presented which relies on the equilibration of cis-dimethyl piperidinedicarboxylate followed by alkylation with phthalimidoethyl triflate.
SYNTHESIS AND CONFIGURATION OF DIASTEREOMERIC 2,4-, 2,5-, AND 2,6-PIPERIDINEDICARBOXYLIC ACIDS AND THEIR DIMETHYL ESTERS
Mastafanova, L. I.,Turchin, K. F.,Evstratova, M. I.,Sheinker, Yu. N.,Yakhontov, L. N.
, p. 305 - 309 (2007/10/02)
The reduction in an acidic medium over a platinum catalysts of 2,4-, 2,5-, and 2,6-pyridinedicarboxylic acids gave cis-2,4-, -2,5-, and -2,6-piperidinedicarboxylic acids, heating of which in an alkaline medium led to thermodynamically equilibrium mixtures of diastereomers.Individual trans-2,5-piperidinecarboxylic acid was isolated.The configurations of the 2,4-, 2,5-, and 2,6-piperidinedicarboxylic acids and their methyl esters were established by means of the PMR spectra.
