98990-64-8

Upstream product

• 13266-91-6 (Z)-1-phenylprop-1-en-1-yl acetate 
• 6209-72-9 4-nitrobenzenesulfonyl peroxide 
• 66323-99-7 trimethyl[(Z)-(1-phenyl-1-propenyl)oxy]silane 
• 61477-33-6 [hydroxy(p-nitrobenezenesulfonyloxy)iodo]benzene 
• 93-55-0 1-phenyl-propan-1-one 
• 138-42-1 p-nitrobenzenesulfonic acid 
• 6084-15-7 2-iodo-1-phenylpropan-1-one 
• 66217-92-3 α-morpholino-β-methylstyrene 

Downstream Products

• 6493-83-0 2-methoxy-1-phenyl-propan-1-one 
• 50739-79-2 2-ethoxy-1-phenyl-propan-1-one 
• 19347-08-1 acetic acid 1-methyl-2-oxo-2-phenyl-ethyl ester 
• 76047-15-9 1-phenyl-2-(1-methylethoxy)propan-1-one 
• 6084-15-7 2-iodo-1-phenylpropan-1-one 
• 35947-99-0 2-azido-1-phenyl-1-propanone 

Relevant academic research and scientific papers

Sodium iodide-catalyzed direct α-alkoxylation of ketones with alcohols via oxidation of α-iodo ketone intermediates

The direct α-alkoxylation of ketones with alcohols via a sodium iodide-catalyzed oxidative cross-coupling has been developed. This protocol enables a range of alkyl aryl ketones to cross couple with an array of alcohols in synthetically useful yields. The mechanistic studies provided solid evidence supporting that an α-iodo ketone was a key reaction intermediate, being converted into an α-alkoxylated ketone via further oxidation to a hypervalent iodine species rather than a common nucleophilic substitution, and was generated from the ketone starting material via a radical intermediate. These new mechanism insights should have an effect on the design of iodide-catalyzed oxidative cross-coupling reactions between nucleophiles.

Highly Efficient α-Organosulfonyloxylation of Carbonyl Compounds under Microwave Irradiation

Iodobenzene diacetate and organosulfonic acid mediated reaction of various carbonyl compounds under solventless microwave irradiation provided α-organosulfonyloxy carbonyl compounds in high yields.

An effective synthesis of α-azido ketones from ketones

One-pot transformation of ketones into α-azido ketones has been achieved by successive treatment with HNIB and NaN3 in acetonitrile.

Efficient method for α-iodination of ketones

α-Iodoketones are prepared in high yields from the initial reaction of various ketones with HNIB in CH3CN and subsequent treatment of potassium iodide or samarium(II) iodide.

A facile synthesis of secondary α-alkoxy or α-acetoxy aromatic ketones

The treatment of HNIB with aromatic ketones and subsequent solvolysis using alcohol or acetic acid in one-pot system makes it possible to give corresponding secondary α-alkoxy or α-acetoxy ketones in high yields.

Synthesis of α-Arylsulfonoxy Ketones from Ketone Derivatives

Silyl enol ethers, and enols can all be efficiently converted to α-arylsulfonoxy ketones by reaction with arylsulfonyl peroxides.