98990-64-8Relevant articles and documents
Sodium iodide-catalyzed direct α-alkoxylation of ketones with alcohols via oxidation of α-iodo ketone intermediates
Zhu, Cuiju,Zhang, Yuanfei,Zhao, Huaiqing,Huang, Shijun,Zhang, Min,Su, Weiping
supporting information, p. 331 - 338 (2015/02/19)
The direct α-alkoxylation of ketones with alcohols via a sodium iodide-catalyzed oxidative cross-coupling has been developed. This protocol enables a range of alkyl aryl ketones to cross couple with an array of alcohols in synthetically useful yields. The mechanistic studies provided solid evidence supporting that an α-iodo ketone was a key reaction intermediate, being converted into an α-alkoxylated ketone via further oxidation to a hypervalent iodine species rather than a common nucleophilic substitution, and was generated from the ketone starting material via a radical intermediate. These new mechanism insights should have an effect on the design of iodide-catalyzed oxidative cross-coupling reactions between nucleophiles.
An effective synthesis of α-azido ketones from ketones
Lee,Kim,Shin
, p. 4271 - 4275 (2007/10/03)
One-pot transformation of ketones into α-azido ketones has been achieved by successive treatment with HNIB and NaN3 in acetonitrile.
A facile synthesis of secondary α-alkoxy or α-acetoxy aromatic ketones
Lee, Jong Chan,Hong, Taiyoung
, p. 4085 - 4090 (2007/10/03)
The treatment of HNIB with aromatic ketones and subsequent solvolysis using alcohol or acetic acid in one-pot system makes it possible to give corresponding secondary α-alkoxy or α-acetoxy ketones in high yields.