99441-44-8

Basic information

• Product Name: 2H-Pyran, tetrahydro-2-[[(2E)-3-phenyl-2-propenyl]oxy]-
• CAS NO: 99441-44-8
• Molecular Formula: C14H18O2
• Molecular Weight: 218.296
• Mol File: 99441-44-8.mol
• Article Data: 65

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, tetrahydro-2-[[(2E)-3-phenyl-2-propenyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, tetrahydro-2-[[(2E)-3-phenyl-2-propenyl]oxy]-(99441-44-8)
• EPA Substance Registry System: 2H-Pyran, tetrahydro-2-[[(2E)-3-phenyl-2-propenyl]oxy]-(99441-44-8)

Safety Data

• Hazardous Substances Data: 99441-44-8(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 104-54-1 3-Phenylpropenol 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 591-50-4 iodobenzene 
• 6089-04-9 3-(tetrahydropyran-2'-yloxy)propyne 
• 122-97-4 3-Phenyl-1-propanol 

Downstream Products

• 104-55-2 3-phenyl-propenal 
• 29268-75-5 3,3-Dichloro-1-phenyl-1-propene 
• 13372-81-1 cinnamaldoxime 
• 1448157-07-0 4-phenyl-3-[(tetrahydro-2H-pyran-2-yloxy)methyl]furoxan 
• 1448157-15-0 3-phenyl-4-[(tetrahydro-2H-pyran-2-yloxy)methyl]furoxan 
• 130485-38-0 c-2-Hydroxymethyl-t-3-phenyl-r-1-trimethylsilylcyclopropane 
• 104-65-4 cinnamyl formate 
• 103-54-8 cinnamyl acetate 
• 13686-96-9 nonane-1,5-diol 

Relevant articles and documents

BiCl3: A versatile catalyst for the tetrahydropyranylation and depyranylation of 1°,2°,3°, allylic, benzylic alcohols, and symmetric diols

Bismuth trichloride as mild reagent, has been found to be a worthful catalyst for tetrahydropyranylation of 1°,2°,3°, allylic, benzylic alcohols, and symmetric di-ols. At room temperature the reagent THP(3,4-dihydro-2H-pyran) was successfully employed as pyranylating agent in presence of BiCl3catalyst without the use of a solvent and the yields of the products were found to be 90-96%. Further, the depyranylation of alcohols was achieved in quantitative yield by simple addition of MeOH using the same catalyst. The developed method was showed good chemo-selectivity in symmetrical diols for mono THP protection.

Magnetic nanoparticle-supported DABCO tribromide: A versatile nanocatalyst for the synthesis of quinazolinones and benzimidazoles and protection/deprotection of hydroxyl groups

1,4-Diazabicyclo[2.2.2]octane tribromide supported on magnetic Fe3O4 nanoparticles (MNPs-DABCO tribromide) as a novel heterogeneous tribromide type compound was found to be an efficient and reusable nanocatalyst for the one-pot synthesis of 2-arylquinazolin-4(3H)-ones and 2-aryl-1H-benzo[d]imidazoles through oxidative cyclization of aldehydes with 2-aminobenzamides and 1,2-phenylenediamine, respectively. Also, MNPs-DABCO tribromide catalyzed trimethylsilylation/tetrahydropyranylation and desilylation/depyranylation of a wide variety of alcohols and phenols through changing the solvent medium at room temperature.

ERK INHIBITORS

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The invention also provides a method of inhibiting ERK2 in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of Formula (I). The invention also provides a method for treating cancer in a patient in need of such treatment, said method comprising administering to said patient an effective amount of at least one compound of Formula (I).