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Cinnamyl formate, an α,β-unsaturated ester, is a flavoring agent and fragrance ingredient known for its balsamic, fruital-floral odor and bittersweet taste reminiscent of apple. It has a taste threshold value of 5 ppm, characterized by a sweet, cinnamon-like, astringent flavor with woody resinous and balsamic nuances. CINNAMYL FORMATE is reported to be found in narcissus flowers.

104-65-4

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104-65-4 Usage

Uses

Used in Flavor and Fragrance Industry:
Cinnamyl formate is used as a flavoring agent for its sweet, cinnamon-like taste and as a fragrance ingredient for its balsamic, fruital-floral odor. Its aroma threshold value allows for detection at 1.0%, contributing a cinnamon spicy, slightly balsamic, cherry fruity scent with berry and tropical nuances to various products.

Preparation

By esterification of cinnamyl alcohol with formic acid.

Flammability and Explosibility

Notclassified

Safety Profile

Moderately toxic by ingestion. See also ESTERS. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.

Metabolism

Cinnamyl formate is hydrolysed by porcine pancreatic lipase 2.6 times more rapidly than is cinnamyl oleate under identical conditions (Brockerhoff, 1970).

Check Digit Verification of cas no

The CAS Registry Mumber 104-65-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 104-65:
(5*1)+(4*0)+(3*4)+(2*6)+(1*5)=34
34 % 10 = 4
So 104-65-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H10O2/c11-9-12-8-4-7-10-5-2-1-3-6-10/h1-7,9H,8H2/b7-4+

104-65-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Cinnamyl Formate

1.2 Other means of identification

Product number -
Other names 2-Propen-1-ol, 3-phenyl-, formate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104-65-4 SDS

104-65-4Relevant academic research and scientific papers

"Counter" Phase Transfer Catalysis by Water-soluble Phosphine Complexes. Catalytic Reduction of Allyl Chlorides and Acetates with Sodium Formate in Two-phase Systems

Okano, Tamon,Moriyama, Yoshiyuki,Konishi, Hisatoshi,Kiji, Jitsuo

, p. 1463 - 1466 (1986)

In the reduction of allyl chlorides and acetates with sodium formate in a heptane-water two-phase system, water-soluble palladium complexes function as a novel type of catalyst which transports the substrate into the aqueous phase and causes it to react with sodium formate.

Hemin Catalyzed Dealkylative Intercepted [2, 3]-Sigmatropic Rearrangement Reactions of Sulfonium Ylides with 2, 2, 2-Trifluorodiazoethane

Yan, Xiaojing,Li, Chang,Xu, Xiaofei,Zhao, Xiaoyong,Pan, Yuanjiang

, p. 2005 - 2011 (2020/05/18)

A dealkylative intercepted [2, 3]-sigmatropic rearrangement reaction of allylic sulfides with 2, 2, 2-trifluorodiazoethane (CF3CHN2) is reported, the commercially available and biocompatible catalyst hemin was found to efficiently catalyze this transformation across a diverse set of allylic sulfides with in situ generated CF3CHN2, providing excellent yields (up to 99%) under mild condition without inert gas protection. In addition, CF3CHN2 exhibited unique reactivity toward this process compared with other frequently used diazo reagents. This work expands the range of carbene-mediated transformations catalyzed by hemin and introduces a concise and general strategy for exploiting new possibility of reactions concerning organosulfides. (Figure presented.).

Efficient Enzymatic Preparation of Flavor Esters in Water

Perdomo, Igor Chiarelli,Gianolio, Stefania,Pinto, Andrea,Romano, Diego,Contente, Martina Letizia,Paradisi, Francesca,Molinari, Francesco

, p. 6517 - 6522 (2019/06/20)

A straightforward biocatalytic method for the enzymatic preparation of different flavor esters starting from primary alcohols (e.g., isoamyl, n-hexyl, geranyl, cinnamyl, 2-phenethyl, and benzyl alcohols) and naturally available ethyl esters (e.g., formate, acetate, propionate, and butyrate) was developed. The biotransformations are catalyzed by an acyltransferase from Mycobacterium smegmatis (MsAcT) and proceeded with excellent yields (80-97%) and short reaction times (30-120 min), even when high substrate concentrations (up to 0.5 M) were used. This enzymatic strategy represents an efficient alternative to the application of lipases in organic solvents and a significant improvement compared with already known methods in terms of reduced use of organic solvents, paving the way to sustainable and efficient preparation of natural flavoring agents.

Photocatalyzed ortho-Alkylation of Pyridine N-Oxides through Alkene Cleavage

Zhou, Wang,Miura, Tomoya,Murakami, Masahiro

supporting information, p. 5139 - 5142 (2018/05/30)

A photocatalyzed reaction of pyridine N-oxides with alkenes gives ortho-alkylated pyridines with cleavage of the carbon–carbon double bond. Benzyl and secondary alkyl groups are incorporated at the ortho position of pyridines in one pot.

Lewis Base Promoted Reduction of CO2 with BH3NH3 into Boryl Formates: CO2 as a Carbon Source in Organic Synthesis Under Mild Conditions

Zhang, Bo,Du, Gaixia,Hang, Wei,Wang, Sheng,Xi, Chanjuan

supporting information, p. 1739 - 1743 (2018/04/24)

Lewis base promoted selective reduction of CO2 into boryl formates by using BH3NH3 as a reductant under mild conditions has been reported. The boryl formates, generated in situ, were shown to be reactive and versatile sources of formyl compounds to create new C–N, C–O, and C–C bonds. The reactivity of the boryl formates to yield formic acid, formamides, formates, secondary alcohols, and benzoheterocyclic rings was investigated.

An Effective Pt-Cu/SiO2 Catalyst for the Selective Hydrogenation of Cinnamaldehyde

Wang, Dong,Zhu, Yujun

, (2018/05/23)

The bimetal catalyst Pt-Cu/SiO2 was prepared by the impregnation method. Its catalytic performance was investigated by the selective hydrogenation of cinnamaldehyde. Pt-Cu/SiO2 exhibited much higher selectivity (64.1%) to cinnamyl al

Application of polydopamine sulfamic acid-functionalized magnetic Fe3O4 nanoparticles (Fe3O4@PDA-SO3H) as a heterogeneous and recyclable nanocatalyst for the formylation of alcohols and amines under solvent-free conditions

Taheri, Sepideh,Veisi, Hojat,Hekmati, Malak

, p. 5075 - 5081 (2017/07/11)

Herein, formylation of structurally different amines and alcohols with ethyl formate was carried out in the presence of a catalytic proportion of sulfonic acid supported on polydopamine (PDA)-encapsulated Fe3O4 nanoparticles as a heterogeneous, recyclable, and greatly efficient catalyst; this method provided the corresponding N-formyl compounds in good to excellent yields under solvent-free conditions. The magnetically catalytic system was recovered, by-passing the time-consuming filtration operation using an external magnet device. This procedure also increases the purity of the product and promises economic and ecological advantages. Furthermore, the recovery and reuse of the catalyst was demonstrated five times without detectable loss in the activity.

N-Heterocyclic Carbene Catalyzed Transformylation

Fernando, Jared E. M.,Levens, Alison,Moock, Daniel,Lupton, David W.

, p. 3505 - 3510 (2017/07/27)

The N-heterocyclic carbene (NHC) catalyzed transformylation has been developed for the conversion of 1°, 2°, and 3° alcohols to the corresponding formates. The reaction employs low catalyst loadings and methyl formate as the formyl transfer reagent. The scope of the reaction is broad with 23 examples reported with good yields (59-96%). The reaction is insensitive to common nitrogen and oxygen protecting groups and can be achieved in the presence of a number of heterocycles.

Selective hydrogenation of cinnamaldehyde to cinnamal alcohol over platinum/graphene catalysts

Ji, Xiwang,Niu, Xiaoyu,Li, Bo,Han, Qing,Yuan, Fulong,Zaera, Francisco,Zhu, Yujun,Fu, Honggang

, p. 3246 - 3253 (2015/02/18)

Catalysts made of Pt nanoparticles dispersed on graphene (X wt%Pt/G, X=2.0, 3.5, and 5.0) were prepared and characterized by XRD, Raman spectroscopy, BET surface area measurements, TEM, and X-ray photoelectron spectroscopy (XPS), and a 3.5 wt% Pt supported on Vulcan Carbon catalyst (3.5 wt%Pt/VC) was included as a reference. Although the mean Pt nanoparticle size is approximately 4.4 nm for all X wt%Pt/G and 3.5 wt%Pt/VC catalysts, cinnamal alcohol was produced with high selectivity only with the graphene-supported catalysts: 92% conversion and 88% selectivity toward cinnamal alcohol were obtained with 3.5 wt%Pt/G. This catalyst also showed good stability in recycling tests. The good selectivity observed with the graphene-based catalysts is attributed to the higher fraction of reduced surface Pt0 atoms seen on the surface of the Pt nanoparticles (determined by XPS). This interpretation is consistent with DFT calculations. Additional π -π interactions between cinnamaldehyde and graphene may also play a role in the selective hydrogenation of cinnamaldehyde.

Formylation of alcohol with formic acid under solvent-free and neutral conditions catalyzed by free I2 or I2 generated in situ from Fe(NO3)3·9H2O/NaI

Amin, Rostami,Ardeshir, Khazaei,Heidar Ali, Alavi-Nik,Zahra, Toodeh-Roosta

experimental part, p. 60 - 64 (2011/10/08)

Different alcohols were formylated by formic acid under solvent-free conditions in the presence of iodine as the catalyst with good-to-high yields at room temperature. I2 generated in situ from Fe(NO3) 3·9H2O/NaI also catalyzed the formylation of the alcohols under solvent-free conditions. This gives a green and efficient reaction at room temperature, in which the use of toxic and corrosive molecular I2 is avoided.

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