99508-49-3

Basic information

• Product Name: Methanone, (2,6-dichlorophenyl)(4-methylphenyl)-
• CAS NO: 99508-49-3
• Molecular Formula: C14H10Cl2O
• Molecular Weight: 265.139
• Mol File: 99508-49-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methanone, (2,6-dichlorophenyl)(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2,6-dichlorophenyl)(4-methylphenyl)-(99508-49-3)
• EPA Substance Registry System: Methanone, (2,6-dichlorophenyl)(4-methylphenyl)-(99508-49-3)

Safety Data

• Hazardous Substances Data: 99508-49-3(Hazardous Substances Data)

Upstream product

• 20082-66-0 trimethyl(2,6-dichlorophenyl)silicium 
• 100-07-2 4-methoxy-benzoyl chloride 
• 50-30-6 2,6-dichlorobenzoic acid 
• 541-73-1 1,3-Dichlorobenzene 
• 108-88-3 toluene 
• 4659-45-4 2,6-Dichlorobenzoyl chloride 

Downstream Products

• 99519-91-2 5-amino-1-(4-[2,6-dichlorobenzoyl]benzyl)-1,2,3-triazole-4-carboxamide 
• 99508-51-7 4-(2,6-dichlorobenzoyl)benzyl azide 
• 99508-50-6 4-(2,6-dichlorobenzoyl)benzyl bromide 

Relevant articles and documents

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Functionalisation in 2 position of benzenes 1,3-disubstituted by para-directing groups has been investigated, involving 2-trimethylsilylated intermediates when the classical methods (particularly these involving the anion in 2 position) are ineffective. Thus 2-trimethylsilyl derivatives of 1,3-dihalo- or 1,3-dimethoxybenzene have been prepared in good yields. Their conversion into the corresponding 1,2,3-trisubstituted benzenes has been conveniently performed upon acetylation, iodination or sulfonation, except in the case of the sulfonation of the 1,3-dimethoxylated compound in which the ipso effect of the silyl group is surpassed by the directing effect of the methoxy substituents. In contrast, whith the same substrate, cyanation in position 2 was successfully carried out using chlorosulfonyl isocyanate: to our knowledge this reaction is the first example of substitution of a trimethylsilyl by a cyano group in the aromatic series.