99585-64-5

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-4'-CHLOROBENZOPHENONE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing medications.
Used in Dye Industry:
In the dye industry, 2-BROMO-4'-CHLOROBENZOPHENONE serves as a key intermediate in the production of dyes, enhancing the color properties and stability of the final products.
Used in Organic Compounds Synthesis:
2-BROMO-4'-CHLOROBENZOPHENONE is utilized as an intermediate in the synthesis of other organic compounds, broadening its applications in various chemical processes and industries.
Used as a Photoinitiator in UV-curable Inks and Coatings:
2-BROMO-4'-CHLOROBENZOPHENONE is employed as a photoinitiator in UV-curable inks and coatings, enabling rapid curing under ultraviolet light and improving the performance and durability of the final products.
Used in the Synthesis of Biologically Active Compounds:
Due to its versatile chemical reactivity, 2-BROMO-4'-CHLOROBENZOPHENONE is used in the synthesis of various biologically active compounds, contributing to the development of new therapeutic agents and enhancing the effectiveness of existing treatments.

InChI:InChI=1/C13H8BrClO/c14-12-4-2-1-3-11(12)13(16)9-5-7-10(15)8-6-9/h1-8H

Upstream product

• 7154-66-7 2-bromobenzoic acid chloride 
• 108-90-7 chlorobenzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 88-65-3 2-bromobenzoic-acid 
• 529-19-1 2-Methylbenzonitrile 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 899425-05-9 2-bromo-N-methoxy-N-methylbenzamide 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 92188-91-5 1-bromo-2-(4-chlorobenzyl)benzene 
• 59666-23-8 2-(4-chlorobenzoyl)benzonitrile 
• 942512-16-5 1-bromo-2-[1-(4-chlorophenyl)ethenyl]benzene 
• 942512-24-5 2-[1-(4-chlorophenyl)ethenyl]-N-phenylthiobenzamide 
• 942512-25-6 2-[1-(4-chlorophenyl)ethenyl]-N-cylohexylthiobenzamide 
• 910239-42-8 2-[1-(4-chlorophenyl)ethenyl]benzonitrile 
• 1380089-40-6 4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazole-5-carbaldehyde 
• 1380089-41-7 (R,E)-N-((4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)methylene)-2-methylpropan e-2-sulfinamide 
• 1380089-42-8 (3S)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate 
• 1380088-08-3 tert-butyl 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetate 
• 1380089-20-2 4-(2-(4-chlorobenzyl)phenyl)-3-methylisoxazol-5-ylmethyl benzoate 
• 1380089-92-8 4-azido-6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepine 
• 1380089-91-7 6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-amine. 
• 1380088-99-2 1-(6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)-3-ethylurea 

Relevant academic research and scientific papers

Chiral electron-rich PNP ligand with a phospholane motif: Structural features and application in asymmetric hydrogenation

Despite the remarkable reactivity that was achieved by a series of transition-metal catalysts with a PNP type ligand, the electron-rich chiral PNP ligands have still been rarely reported because of the difficulties in synthesis and the nature of air-sensitivity. Herein, we report a novel chiral PNP ligand (Heng-PNP) with both a rigid backbone and a bulky tert-butyl group on the phospholane motif. We successfully obtained its divalent iron complex. The chiral environment of its Ir(III) complex was also discussed with quadrant analysis. This tridentate ligand was applied in iridium-catalyzed asymmetric hydrogenation of challenging diaryl ketones: up to 98% ee and 500 TON are achieved. Computational study showed that the twist of conjugate aryl group in the substrate (induced by the special chiral pocket of Ir/Heng-PNP complex) leads to the energy difference in the enantiodetermining step.

Palladium(II)-catalyzed Intermolecular Cascade Cyclization of Methylenecyclopropanes with Aromatic Alkynes: Construction of Spirocyclic Compounds Containing Indene and 1,2-Dihydronaphthalene Moieties

A palladium(II)-catalyzed intermolecular cascade cyclization of methylenecyclopropanes with aromatic alkynes is reported in this paper. The reaction involves a migratory insertion of alkyne, an intramolecular Heck-type reaction, and β-H elimination, providing a series of spirocyclic compounds containing indene and 1,2-dihydronaphthalene moieties in moderate to excellent yields upon heating.

Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes

The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migration process is the key for success.

Borylation of Olefin C-H Bond via Aryl to Vinyl Palladium 1,4-Migration

The aryl to vinyl palladium 1,4-migration was realized for the first time. The generated alkenyl palladium species was trapped by diboron reagents under Miyaura borylation conditions, providing a new method to synthesize β,β-disubstituted vinylboronates. The excellent regioselectivity and broad substrate scope were observed for this novel transformation.

Palladium(II)-catalyzed desulfitative synthesis of aryl ketones from sodium arylsulfinates and nitriles: Scope, limitations, and mechanistic studies

A fast and efficient protocol for the palladium(II)-catalyzed production of aryl ketones from sodium arylsulfinates and various organic nitriles under controlled microwave irradiation has been developed. The wide scope of the reaction has been demonstrated by combining 14 sodium arylsulfinates and 21 nitriles to give 55 examples of aryl ketones. One additional example illustrated that, through the choice of the nitrile reactant, benzofurans are also accessible. The reaction mechanism was investigated by electrospray ionization mass spectrometry and DFT calculations. The desulfitative synthesis of aryl ketones from nitriles was also compared to the corresponding transformation starting from benzoic acids. Comparison of the energy profiles indicates that the free energy requirement for decarboxylation of 2,6-dimethoxybenzoic acid and especially benzoic acid is higher than the corresponding desulfitative process for generating the key aryl palladium intermediate. The palladium(II) intermediates detected by ESI-MS and the DFT calculations provide a detailed understanding of the catalytic cycle. (Figure Presented).

BROMODOMAIN INHIBITORS AND USES THEREOF

The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.

Analogues of fenarimol are potent inhibitors of trypanosoma cruzi and are efficacious in a murine model of chagas disease

We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogues with low nM IC50s in a T. cruzi whole cell in vitro assay. Lead compounds suppressed blood parasitemia to virtually undetectable levels after once daily oral dosing in mouse models of T. cruzi infection. Compounds are chemically tractable, allowing rapid optimization of target biological activity and drug characteristics. Chemical and biological studies undertaken in the development of the fenarimol series toward the goal of delivering a new drug candidate for Chagas disease are reported.