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Levosulpiride

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Name

Levosulpiride

EINECS 239-753-7
CAS No. 23672-07-3 Density 1.236 g/cm3
PSA 110.11000 LogP 2.66660
Solubility N/A Melting Point 183-186 °C(lit.)
Formula C15H23N3O4S Boiling Point N/A
Molecular Weight 341.431 Flash Point N/A
Transport Information N/A Appearance white crystalline powder
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 23672-07-3 (Levosulpiride) Hazard Symbols N/A
Synonyms

Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-, (S)-;o-Anisamide, N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-sulfamoyl-, (-)- (8CI);(-)-Sulpiride;L-Sulpiride;Levobren;Levopraid;

Article Data 3

Levosulpiride Specification

Levosulpiride, its cas register number is 23672-07-3. It also can be called (S)-(-)-Sulpiride; (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide;  (-)-N-(((S)-1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide; Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- (9CI); o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-, (S)-(-)- . It is an antipsychotic.  Levosulpiride is used in the treatment of psychoses, particularly negative symptoms of schizophrenia, anxiety disorders, dysthymia, vertigo, dyspepsia, irritable bowel syndrome and premature ejaculation.

Physical properties about Levosulpiride are: (1)ACD/LogP: 0.776; (2)ACD/LogD (pH 5.5): -2.24; (3)ACD/LogD (pH 7.4): -1.08; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 7; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 6; (11)Index of Refraction: 1.552; (12)Molar Refractivity: 88.183 cm3; (13)Molar Volume: 276.104 cm3; (14)Polarizability: 34.958 10-24cm3; (15)Surface Tension: 45.8950004577637 dyne/cm; (16)Density: 1.237 g/cm3

You can still convert the following datas into molecular structure:
(1)InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21);
(2)InChIKey=BGRJTUBHPOOWDU-UHFFFAOYSA-N;
(3)Smilesc1(c(ccc(c1)S(N)(=O)=O)OC)C(NC[C@@H]1[N@@](CCC1)CC)=O;

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 170mg/kg (170mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 17, Pg. 437, 1982.
mouse LD50 oral 2450mg/kg (2450mg/kg)   Drugs of the Future. Vol. 12, Pg. 944, 1987.
rabbit LD50 intravenous 42mg/kg (42mg/kg)   Drugs of the Future. Vol. 12, Pg. 944, 1987.
rabbit LD50 oral > 1500mg/kg (1500mg/kg)   Drugs of the Future. Vol. 12, Pg. 944, 1987.
rat LD50 intraperitoneal 270mg/kg (270mg/kg)   Drugs of the Future. Vol. 12, Pg. 944, 1987.
rat LD50 intravenous 53mg/kg (53mg/kg)   Drugs of the Future. Vol. 12, Pg. 944, 1987.
rat LD50 oral 2600mg/kg (2600mg/kg)   Drugs of the Future. Vol. 12, Pg. 944, 1987.

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