An environmentally friendly and efficient reaction of 4-alkoxy-1,1,1-trihalo-3-alken-2-ones and cyanoacetohydrazide

February 29, 2024

• Title:       

  An environmentally friendly and efficient reaction of 4-alkoxy-1,1,1-trihalo-3-alken-2-ones and cyanoacetohydrazide

• Image Source:

  Ionic liquid and Lewis acid combination in the synthesis of novel (E)-1-(benzylideneamino)-3-cyano-6-(trifluoromethyl)-1H-2-pyridones

• Mark:

  Scheme 1

• Associated context:

  The combination of a classical base-catalyzed route and ionic liquids could afford a new green methodology to synthesize 2-pyridones. In this context, and in connection with our ongoing interest in the synthesis and evaluation of new trifluoromethylated heterocyclic compounds, we report herein an environmentally friendly and efficient reaction of 4-alkoxy-1,1,1-trihalo-3-alken-2-ones and cyanoacetohydrazide using a new and interesting catalytic system of base/Lewis acid and [BMIM][BF4] as a recyclable solvent (Scheme 1).