Strategies for Biaryl Construction (X ) Cl, Br, I, OTf, etc.)

March 01, 2024

• Title:       

  Strategies for Biaryl Construction (X ) Cl, Br, I, OTf, etc.) 

• Image Source:

  Intermodular decarboxylative direct C-3 arylation of indoles with benzoic acids

• Mark:

  Scheme 1

• Associated context:

  Palladium catalyzed cross-coupling reactions between orga-nometallic and haloarene moieties are among the most employed methodologies for the synthesis of biaryls (Scheme  1, eq 1).¹ However, these methodologies present intrinsic disadvantages, namely the need for prefunctionalization of both coupling partners and the generation of stoichiometric amounts of often toxic metal salts.