Proposed modification of curcuminÕs b-diketone linker region.

March 06, 2024

• Title:       

  Proposed modification of curcumin's β-diketone linker  

  region.

• Image Source:

  Synthesis and biological evaluation of aromatic enones related to curcumin

• Mark:

  Figure 3

• Associated context:

  By dividing the molecule into specific and modifiable regions of interest, a simple, yet effective, pharmacophore model for the curcumin analogs was developed. Each individual region can be modified independently of the others in order to aid in the systematic refinement of the search for increasingly effective curcumin derivatives. In the current study, compounds with an abbreviated linker between the two aromatic regions comprised the primary focus. The linker was shortened from curcumin's original b-diketone to a more compact singular enone moiety (B⁰) [see Fig. 3].