Key structural regions of curcumin

March 06, 2024

• Title:       

  Key structural regions of curcumin

• Image Source:

  Synthesis and biological evaluation of aromatic enones related to curcumin

• Mark:

  Figure 1

• Associated context:

  It has been postulated that the biological efficacy of curcumin arises from the electrophilic nature of its central b-diketone component.^15,16 The enone derivatives selected for investigation retain this essential characteristic, while at the same time simplifying the overall structure of the molecule. In an effort to develop a robust pharmacophoric model and understand the basis for biological activity, the molecular structure of curcumin can be subdivided into three key regions: two substituted aromatic moieties (A and C) joined together by a conjugated b-diketone linker (B) [see Fig. 2].