14590-52-4Relevant articles and documents
N3-CYCLICALLY SUBSTITUTED THIENOURACILS AND USE THEREOF
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, (2020/02/05)
The present application relates to novel thieno[2,3-d]pyrimidine-2,4-dione (“thienouracil”) derivatives having cyclic substituents in the 3 position, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of pulmonary and cardiovascular disorders and of cancer.
SUBSTITUTED CARBOXAMIDES
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Page/Page column 16-17, (2008/12/08)
This application relates to a substituted carboxamide compound of formula I, or a pharmaceutically acceptable salt thereof, as defined herein, a pharmaceutical composition thereof, and its use in treating pain.
184. Stereoselective Hydrolysis of Substituted Cyclopropanedicarboxylates with Pig Liver Esterase
Walser, Paula,Renold, Peter,N'Goka, Victor,Hosseinzadeh, Fatemeh,Tamm, Christoph
, p. 1941 - 1952 (2007/10/02)
The hydrolysis of the meso-cyclopropane-1,2-dicarboxylates 1a-3a, 4, 5a, 6a, and 9, containing various substituents at C(3), and of the rac-3-phenylcyclopropane-1,2-dicarboxylates 7a, 8a, and 10 with pig liver esterase (PLE) is described.The stereoselectivity and absolute configurations of the products were determined.An interpretation of results was attempted on the basis of a recent active-site model for PLE.
1-Aryl-2,2-dimethyl-1,3-propanediols as chiral auxiliares. Acetal formation with α,β-unsaturated aldehydes and analysis of the stereochemistry of cyclopropanation
Ebens, Rijko,Kellogg, Richard M.
, p. 552 - 560 (2007/10/02)
Optically pure 1-aryl- (phenyl and 2-chlorophenyl) 1,3-propanediols, 1a and 1b, condense smoothly with aldehydes to provide the corresponding cyclic acetals 3.Except in cases that the aldehyde is substituted at the α-carbon atom, a single product is obtai
