1618102-42-3Relevant articles and documents
Copper-free catalytic click chemical module molecule and application of copper-free catalytic click chemical module molecule in medicine
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Paragraph 0099, (2017/08/28)
The invention relates to the field of chemistry and a preparation, and more specifically relates to preparation of a copper-free catalytic click chemical module molecule and an application of the copper-free catalytic click chemical module molecule in construction of a drug delivery carrier and surface multifunctional modification. According to the invention, a cyclooctyne derivative and a liposome matrix are used for forming stable liposome through a dispersing method; a physical effect is used for efficiently loading the gene treatment medicines or chemotherapeutics, furthermore, the stable drug liposome is formed; finally, through a click chemical reaction of copper-free catalysis, and the azide derivatives having different functions are modified to the surface of the drug liposome according to the requirement and the formation of a chemical bond. The method can avoid the toxicity of heavy metal copper ions, and overcomes the disadvantages of DNA degradation and protein denaturation brought by copper catalysis. Under condition that efficient and stable medicine carrying is guaranteed, the construction of the multifunctional drug delivery carrier with safety, stabilization and high efficiency can be obtained.
Copper-free click-chemistry platform to functionalize cisplatin prodrugs
Pathak, Rakesh K.,McNitt, Christopher D.,Popik, Vladimir V.,Dhar, Shanta
supporting information, p. 6861 - 6865 (2014/06/09)
The ability to rationally design and construct a platform technology to develop new platinum(IV) [PtIV] prodrugs with functionalities for installation of targeting moieties, delivery systems, fluorescent reporters from a single precursor with the ability to release biologically active cisplatin by using well-defined chemistry is critical for discovering new platinum-based therapeutics. With limited numbers of possibilities considering the sensitivity of PtIV centers, we used a strain-promoted azide-alkyne cycloaddition approach to provide a platform, in which new functionalities can easily be installed on cisplatin prodrugs from a single PtIV precursor. The ability of this platform to be incorporated in nanodelivery vehicle and conjugation to fluorescent reporters were also investigated.
