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Cas Database |
| Name |
Triptolide |
EINECS | 300-006-3 |
| CAS No. | 38748-32-2 | Density | 1.48 g/cm3 |
| PSA | 84.12000 | LogP | 1.10310 |
| Solubility | soluble in DMSO | Melting Point |
226-227 °C |
| Formula | C20H24O6 | Boiling Point | 601.7 °C at 760 mmHg |
| Molecular Weight | 360.407 | Flash Point | 220.7 °C |
| Transport Information | N/A | Appearance | White crystalline solid |
| Safety | 22-24/25 | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
(-)-Triptolide;NSC 163062;PG 490;[3bS-(3ba,4aa,5aR*,6b,6ab,7ab,7ba,8aR*,8bb)]-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one; |
Article Data | 9 |
Triptolide Chemical Properties
Name : Triptolide
Molecular Structure : 
Molecular Formula : C20H24O6
Molecular Weight : 360.41
CAS Registry Number : 38748-32-2
storage temp : 2-8°C
form : solid
solubility :soluble
color :white to off-white
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease Triptolide is a potent, biologically active compound isolated from the medicinal 'Thunder God Vine' Tripterygium wilfordii Hook F. The TCM tea Lei Gong Teng made from this plant has been used for centuries, as a therapeutic against cancer, inflammation, and auto-immune diseases. Crews and colleagues showed that triptolide causes cell growth arrest in certain cell types.
Triptolide Uses
Diterpenoid triepoxide with immunosuppressant
antitumor properties
Triptolide Toxicity Data With Reference
| 1. | ipr-mus LD50:900 µg/kg | CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. 2 (1981),70. | ||
| 2. | ivn-mus LD50:800 µg/kg | CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. 2 (1981),70. | ||
| 3. | ivn-dog LDLo:160 µg/kg | CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. 2 (1981),70. |
Triptolide Safety Profile
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