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Name	2-Piperidineethanol	EINECS	216-059-2
CAS No.	1484-84-0	Density	0.939 g/cm³
PSA	32.26000	LogP	0.83970
Solubility	soluble in water	Melting Point	38-40 °C(lit.)
Formula	C₇H₁₅NO	Boiling Point	234.5 °C at 760 mmHg
Molecular Weight	129.202	Flash Point	102.2 °C
Transport Information	UN 3263 8/PG 2	Appearance	off-white solid
Safety	26-27-28-36/37/39-45-24/25	Risk Codes	20/21/22-34-36/37/38
Molecular Structure		Hazard Symbols	C,Xi
Synonyms	2-(2-Hydroxyethyl)piperidine;2-(2-Piperidinyl)ethanol;2-Piperidine-2-yl-ethanol;NSC 9261;

2-Piperidineethanol Synthetic route

: 103-74-2
2-(2-Hydroxyethyl)pyridine

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With 1,4-dioxane; nickel at 160℃; under 191232 Torr; Hydrogenation;
With ethanol; nickel at 150℃; under 95616 Torr; Hydrogenation;
With acetic acid; platinum Hydrogenation;

: 134256-32-9, 134256-31-8, 134256-33-0, 119204-13-6
N-benzyl-2-(2-hydroxyethyl)piperidine

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With palladium on activated charcoal; ammonium formate In methanol for 12h; Heating; Yield given;

α-picolylcarbinol: α-picolylcarbinol

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With ethanol; sodium

α-picolyl-carbinol: α-picolyl-carbinol

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With ethanol; sodium

: 110-89-4
piperidine

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 30 percent / H2O2, sodium tungstate dihydrate / methanol / under 5 deg C, then Rt, 24 h 2: CH2Cl2 / 12 h / Heating 3: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h 4: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating View Scheme

: 119204-12-5
2-isobutoxyhexahydroisoxazolo<2,3-a>-pyridine

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: CH2Cl2 / 12 h / Heating 2: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h 3: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating View Scheme

: 119204-19-2
(2S,3aR)-8-Benzyl-2-isobutoxy-hexahydro-isoxazolo[2,3-a]pyridin-8-ium; bromide

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h 2: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating View Scheme

: 1885-14-9
phenyl chloroformate

A: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

B 3-(dimethylamino)propyl 2-[2-(hydroxyethyl)]piperidinecarboxylate: 3-(dimethylamino)propyl 2-[2-(hydroxyethyl)]piperidinecarboxylate

Conditions

Conditions	Yield
pyridine

: 1885-14-9
phenyl chloroformate

A: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

B 3-chloropropyl 2-[2-(hydroxyethyl)]piperidinecarboxylate: 3-chloropropyl 2-[2-(hydroxyethyl)]piperidinecarboxylate

: 103-74-2
2-(2-Hydroxyethyl)pyridine

: 7440-18-8
ruthenium

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

2-Piperidineethanol Chemical Properties

Structure of 2-Piperidineethanol (CAS NO.1484-84-0):

IUPAC Name: 2-piperidin-2-ylethanol
Empirical Formula: C₇H₁₅NO
Molecular Weight: 129.2001
EINECS: 216-059-2
Index of Refraction: 1.454
Molar Refractivity: 37.26 cm³
Molar Volume: 137.5 cm³ Polarizability: 14.77×10^-24cm³
Surface Tension: 34.6 dyne/cm
Density: 0.939 g/cm³
Flash Point: 102.2 °C
Enthalpy of Vaporization: 54.78 kJ/mol
Melting Point: 38-40 °C(lit.)
Boiling Point: 234.5 °C at 760 mmHg
Vapour Pressure: 0.00967 mmHg at 25°C
Water Solubility: soluble
Physical Appearance: Off-White Solid
Product Categories: Alcohols and Derivatives;Heterocycles;Piperidine;Alkohols;Amines;Chiral Reagents
Synonyms of 2-Piperidineethanol (CAS NO.1484-84-0): 2-(2-Hydroxyethyl)piperidine ; 2-Piperidine ethanol ; 2-Piperidin-2-ylethanol .

2-Piperidineethanol Uses

2-Piperidineethanol (CAS NO.1484-84-0) is used in preparation of a novel class of pyrazolopyrimidines as inhibitors of protein and checkpoint kinases, also used in treatment and prophylaxis of HCV infection and other diseases such as cancer.

2-Piperidineethanol Safety Profile

Hazard Codes: Corrosive C, Irritant Xi
Risk Statements: 20/21/22-34-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-27-28-36/37/39-45-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S24/25:Avoid contact with skin and eyes.
RIDADR: UN 3263 8/PG 2
WGK Germany: 3

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