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3,4-Dihydroxybenzaldehyde

  • Name 3,4-Dihydroxybenzaldehyde
  • EINECS205-377-7
  • CAS No. 139-85-5
  • Density1.409 g/cm3
  • PSA57.53000
  • LogP0.91030
  • SolubilityWater solubility: 50 g/L (20 °C)
  • Melting Point150-157 °C(lit.)
  • FormulaC7H6O3
  • Boiling Point295.4 °C at 760 mmHg
  • Molecular Weight138.123
  • Flash Point146.7 °C
  • Transport InformationN/A
  • Appearancebrown powder
  • Safety26-37/39
  • Risk Codes36/37/38
  • Molecular Structure
    Molecular Structure of 139-85-5 (Protocatechualdehyde)
  • Hazard SymbolsIrritantXi
  • SynonymsIrritantXi
  • Article Data150

3,4-Dihydroxybenzaldehyde Synthetic route

121-33-5

vanillin

139-85-5

3,4-dihydroxybenzaldehyde

Conditions
ConditionsYield
With boron tribromide In dichloromethane at 4℃; for 1h;100%
With boron tribromide-dimethyl sulfide complex In 1,2-dichloro-ethane at 83.5℃; for 0.1h;99.3%
Stage #1: vanillin With boron tribromide-dimethyl sulfide complex In dichloromethane at 0 - 20℃; Inert atmosphere;
Stage #2: With water In methanol; dichloromethane at 0℃; for 0.166667h; Inert atmosphere;
99%
621-59-0

isovanillin

139-85-5

3,4-dihydroxybenzaldehyde

Conditions
ConditionsYield
Stage #1: isovanillin With pyridine; iodine; aluminium In acetonitrile for 18h; Reflux;
Stage #2: With hydrogenchloride In water; acetonitrile at 20℃;
99%
With aluminium(III) iodide In dimethyl sulfoxide; acetonitrile at 80℃; for 18h;95%
With aluminium(III) iodide; dimethyl sulfoxide In acetonitrile at 80℃; for 18h;95%
120-57-0

piperonal

139-85-5

3,4-dihydroxybenzaldehyde

Conditions
ConditionsYield
With boron trichloride - methyl sulfide complex In 1,2-dichloro-ethane at 83.5℃; for 29.5h; other reagent;98.5%
With aluminium(III) iodide; tetra-(n-butyl)ammonium iodide In cyclohexane for 1.5h; Heating;84%
With titanium tetrachloride In dichloromethane at -20 - -10℃; for 4h; Inert atmosphere;68.4%
6515-06-6

3,4-bis-methoxymethoxy-benzaldehyde

139-85-5

3,4-dihydroxybenzaldehyde

Conditions
ConditionsYield
With toluene-4-sulfonic acid In neat (no solvent, solid phase) at 20℃; for 0.583333h; Green chemistry;98%
138490-94-5

2-iodoisovanillin

139-85-5

3,4-dihydroxybenzaldehyde

Conditions
ConditionsYield
In [(2)H6]acetone; dichloromethane96.1%
121-32-4

4-hydroxy-3-ethoxybenzaldehyde

139-85-5

3,4-dihydroxybenzaldehyde

Conditions
ConditionsYield
With aluminium(III) iodide In dimethyl sulfoxide; acetonitrile at 80℃; for 18h;96%
With aluminium(III) iodide; dimethyl sulfoxide In acetonitrile at 80℃; for 18h;95%
With aluminium(III) iodide; calcium oxide In acetonitrile at 80℃; for 18h;93%
102-32-9

3,4-dihydroxyphenylacetate

139-85-5

3,4-dihydroxybenzaldehyde

Conditions
ConditionsYield
With dipotassium peroxodisulfate In water at 90℃; for 12h; Green chemistry;63%
120-80-9

benzene-1,2-diol

139-85-5

3,4-dihydroxybenzaldehyde

Conditions
ConditionsYield
62.4%
120-14-9

3,4-dimethoxy-benzaldehyde

A

121-33-5

vanillin

B

139-85-5

3,4-dihydroxybenzaldehyde

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; potassium carbonate; thiophenol for 0.25h; Heating;A 58%
B 20%
4383-06-6

3-hydroxy-4-methoxybenzyl alcohol

139-85-5

3,4-dihydroxybenzaldehyde

Conditions
ConditionsYield
Stage #1: 3-hydroxy-4-methoxybenzyl alcohol With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In tetrahydrofuran at 20℃; Darkness;
Stage #2: With sodium dithionite; water In tetrahydrofuran Darkness;
56%

3,4-Dihydroxybenzaldehyde Specification

3,4-Dihydroxybenzaldehyde, its cas register number is 139-85-5. It also can be called Protocatechualdehyde; Rancinamycin IV; and 4-Formyl-1,2-dihydroxybenzene. It is hazardous, so the first aid measures and others should be known. In addition, 3,4-Dihydroxybenzaldehyde could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: Carbon monoxide, carbon dioxide.  3,4-Dihydroxybenzaldehyde is an important pharmaceutical intermediate, and can be used for synthesis of antibiotics and anti-inflammatory drugs.

Physical properties about 3,4-Dihydroxybenzaldehyde are: (1)ACD/LogP: 0.934; (2)ACD/LogD (pH 5.5): 0.93; (3)ACD/LogD (pH 7.4): 0.72; (4)ACD/BCF (pH 5.5): 2.99; (5)ACD/BCF (pH 7.4): 1.84; (6)ACD/KOC (pH 5.5): 76.12; (7)ACD/KOC (pH 7.4): 46.86; (8)#H bond acceptors: 3; (9)#H bond donors: 2; (10)Index of Refraction: 1.674 ; (11)Molar Refractivity: 36.769 cm3; (12)Molar Volume: 97.959 cm3; (13)Polarizability: 14.576 10-24cm3; (14)Surface Tension: 69.0270004272461 dyne/cm; (15)Density: 1.41 g/cm3; (16)Flash Point: 146.695 °C; (17)Enthalpy of Vaporization: 55.655 kJ/mol; (18)Boiling Point: 295.418 °C at 760 mmHg; (19)Vapour Pressure: 0.00100000004749745 mmHg at 25°C

When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing;
3. Wear suitable gloves and eye/face protection;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C7H6O3/c8-4-5-1-2-6(9)7(10)3-5/h1-4,9-10H;
(2)InChIKey=IBGBGRVKPALMCQ-UHFFFAOYSA-N;
(3)Smilesc1(cc(c(O)cc1)O)C=O

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 205mg/kg (205mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Annales Pharmaceutiques Francaises. Vol. 15, Pg. 461, 1957.
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07875,

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