Basic information
- Name:
5-Methoxytryptamine hydrochloride
- CAS No.:
66-83-1
- Molecular Structure:
- Formula:
- C11H15ClN2O
- Molecular Weight:
- 226.73
- Synonyms:
- 1H-Indole-3-ethanamine,5-methoxy-, monohydrochloride (9CI);Indole, 3-(2-aminoethyl)-5-methoxy-,monohydrochloride (8CI);5-Methoxytryptamine chloride;5-Methoxytryptaminemonohydrochloride;Mexamin;Mexamine;
- EINECS:
- 200-637-6
- Melting Point:
- 246 °C
- Boiling Point:
- 380 °C at 760 mmHg
- Flash Point:
- 183.6 °C
- Appearance:
- white to beige crystalline powder
- Hazard Symbols:
Xn- Risk Codes:
- 22-36/37/38-20/21/22
- Safety Description:
- 36-26 Details
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Chemistry
Molecular structure of 5-Methoxytryptamine hydrochloride (CAS NO.66-83-1) is:
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Product Name: 5-Methoxytryptamine hydrochloride
CAS Registry Number: 66-83-1
IUPAC Name: 2-(5-methoxy-1H-indol-3-yl)ethanamine hydrochloride
Molecular Weight: 226.7026 [g/mol]
Molecular Formula: C11H15ClN2O
H-Bond Donor: 3
H-Bond Acceptor: 2
EINECS: 210-153-7
Sensitive: Hygroscopic
Melting Point: 246 °C
Surface Tension: 50.5 dyne/cm
Density: 1.171 g/cm3
Flash Point: 183.6 °C
Enthalpy of Vaporization: 62.81 kJ/mol
Boiling Point: 380 °C at 760 mmHg
Vapour Pressure: 5.61E-06 mmHg at 25°C
Product Categories: Tryptamines;Aminomethyl's;Pyrroles & Indoles;Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Pyrroles & Indoles
Uses
5-Methoxytryptamine hydrochloride (CAS NO.66-83-1) is used for a metabolite of melatonin.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 2500ug/kg (2.5mg/kg) | CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Farmakologiya i Toksikologiya Vol. 26, Pg. 10, 1963. |
| mouse | LD50 | intraperitoneal | 227mg/kg (227mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 94, Pg. 1620, 1974. | |
| mouse | LD50 | intravenous | 103mg/kg (103mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 23, Pg. T125, 1964. |
| mouse | LD50 | oral | 580mg/kg (580mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 23, Pg. T125, 1964. |
| mouse | LD50 | subcutaneous | 620mg/kg (620mg/kg) | Russian Pharmacology and Toxicology Vol. 35, Pg. 2, 1972. | |
| rabbit | LDLo | intravenous | 75mg/kg (75mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Farmakologiya i Toksikologiya Vol. 26, Pg. 10, 1963. |
| rat | LDLo | intravenous | 6mg/kg (6mg/kg) | Russian Pharmacology and Toxicology Vol. 33, Pg. 246, 1970. |
Safety Profile
Hazard Codes: 
Xn
Risk Statements: 22-36/37/38-20/21/22
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36-26
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: NL4059000
F: 10
HazardClass: IRRITANT
Specification
5-Methoxytryptamine hydrochloride (CAS NO.66-83-1) also can be called 3-(2-Aminoethyl)-5-methoxyindole hydrochloride ; Mexamine HCl ; Indole, 3-(2-aminoethyl)-5-methoxy-, hydrochloride ; and; 5-Methoxy-1H-indole-3-ethylamine monohydrochloride .It is a white to beige crystalline powder.
