Dexamethasone (50-02-2),Dexamethasone (50-02-2) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Dexamethasone
CAS No.:
50-02-2
Molecular Structure:
Formula:
C₂₂H₂₉FO₅
Molecular Weight:
392.46
Deleted CAS:
906422-84-2|
Synonyms:
Diodex;Etacortilen;Fluormone;Fluorocort;Gammacorten;HL-Dex;Hexadecadrol;Hexadrol;Isopto-Dex;Loverine;Luxazone;Millicorten;Oradexon;Pet-Derm III;Prednisolone F;Superprednol;Surodex;Visumetazone;Pregna-1,4-diene-3,20-dione,9-fluoro-11,17,21-trihydroxy-16-methyl-, (11b,16a)-;Pregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy-16a-methyl- (6CI,8CI);1-Dehydro-16a-methyl-9a-fluorohydrocortisone;16a-Methyl-9a-fluoro-D1-hydrocortisone;16a-Methyl-9a-fluoroprednisolone;9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione;9a-Fluoro-16a-methyl-1,4-pregnadiene-11b,17a,21-triol-3,20-dione;9a-Fluoro-16a-methyl-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione;9a-Fluoro-16a-methylprednisolone;Adexone;Aeroseb-Dex;Aphtasolon;Aphthasolone;Azium;Calonat;Corsone;Decacort;Decaderm;Decadron;Decadron A;Dekort;Delipos;Dergramin;Desameton;Dexa-Cortidelt;Dexa-Scheroson;Dexacortin;Dexalona;Dexamethasone alcohol;Dexapolcort;Dexaprol;Dexason;Dexinoral;Dexmethsone;Dexonium;Dinormon;
EINECS:
200-003-9
Density:
1.32 g/cm³
Melting Point:
262-264 °C(lit.)
Boiling Point:
568.2 °C at 760 mmHg
Flash Point:
297.5 °C
Solubility:
10 mg/100 mL (25 °C) in water
Appearance:
White crystalline solid
Hazard Symbols:
Xn, Xi
Risk Codes:
43-40-36/37/38-20/21/22
Safety Description:
36/37-45-36-26-22 Details

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Chemistry

IUPAC Name: (8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Empirical Formula: C₂₂H₂₉FO₅
Molecular Weight: 392.4611
Index of Refraction: 1.591
Molar Refractivity: 100.23 cm³
Molar Volume: 296.2 cm³
Surface Tension: 56.5 dyne/cm
Density: 1.32 g/cm³
Flash Point: 297.5 °C
Enthalpy of Vaporization: 97.96 kJ/mol
Boiling Point: 568.2 °C at 760 mmHg
Vapour Pressure: 2.81E-15 mmHg at 25 °C
Melting point: 262-264 °C(lit.)
Storage tempreture: 2-8 °C
Solubility: Ethanol: 1 mg/mL
Appearance: White crystalline solid
Product Category of Dexamethasone (CAS NO.50-02-2): Active Pharmaceutical Ingredients;Antitumors for Research and Experimental Use;Biochemistry;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds

Uses

Dexamethasone (CAS NO.50-02-2) is used to treat many inflammatory and autoimmune conditions. If given in high doses, it is useful to counteract allergic anaphylactic shock. It is used in transvenous screw-in cardiac pacing leads to minimize the inflammatory response of the myocardium. In oncology, it is given to cancer patients undergoing chemotherapy to counteract certain side-effects of their antitumor treatment. It is also used in the treatment of high altitude cerebral edema as well as pulmonary edema. Dexamethasone is also used in a diagnostic context namely in its property to suppress the natural pituitary-adrenal axis. And combined with marbofloxacin and clotrimazole, dexamethasone is available under the name Aurizon , CAS number 115550-35-1, and used to treat difficult ear infections, especially in dogs.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	410mg/kg (410mg/kg)		Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 281, 1970.
mouse	LD50	subcutaneous	4400mg/kg (4400mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
rabbit	LD50	subcutaneous	7200ug/kg (7.2mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984.
rat	LD50	intraperitoneal	54mg/kg (54mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984.
rat	LD50	oral	> 3gm/kg (3000mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984.
rat	LD50	subcutaneous	14mg/kg (14mg/kg)		Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.
women	TDLo	multiple routes	4759ug/kg/18D (4.759mg/kg)	KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Intensive Care Medicine. Vol. 21, Pg. 238, 1995.

Safety Profile

Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 43-40-36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R40:Limited evidence of a carcinogenic effect.
R43:May cause sensitization by skin contact.
Safety Statements: 36/37-45-36-26-22
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Specification

Dexamethasone , its cas register number is 50-02-2. It also can be called 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione . It is a potent synthetic member of the glucocorticoid class of steroid hormones, and acts as an anti-inflammatory and immunosuppressant. It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately.