Basic information
- Name:
Dypyridamole
- CAS No.:
58-32-2
- Molecular Structure:
- Formula:
- C24H40N8O4
- Molecular Weight:
- 504.72
- Synonyms:
- Ethanol,2,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetra-(6CI,8CI);2,2',2'',2'''-[[4,8-Dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl]dinitrilo]tetraethanol;2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine;Anginal;Apricor;Cardioflux;Cardoxil;Cardoxin;Cleridium;Coronarine;Corosan;Coroxin;Curantyl;Gulliostin;Kurantil;Peridamol;Persantin;Persantine;Piroan;Prandiol;
- EINECS:
- 200-374-7
- Density:
- 1.352 g/cm3
- Melting Point:
- 165-166 °C(lit.)
- Boiling Point:
- 806.5 °C at 760 mmHg
- Flash Point:
- 441.5 °C
- Solubility:
- soluble in DMSO
- Appearance:
- Yellow Powder
- Hazard Symbols:
Xi- Risk Codes:
- 36/37/38
- Safety Description:
- 26-36 Details
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Chemistry
Molecular Structure of Dypyridamole (CAS NO.58-32-2):
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IUPAC Name: 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
Molecular Formula: C24H40N8O4
Molecular Weight: 504.63
EINECS: 200-374-7
H bond acceptors: 12
H bond donors: 4
Freely Rotating Bonds: 16
Polar Surface Area: 101.44Å2
Index of Refraction: 1.67
Molar Refractivity: 139.39 cm3
Molar Volume: 373 cm3
Surface Tension: 81.5 dyne/cm
Density: 1.352 g/cm3
Flash Point: 441.5 °C
Enthalpy of Vaporization: 122.94 kJ/mol
Boiling Point: 806.5 °C at 760 mmHg
Vapour Pressure: 1.82E-27 mmHg at 25°C
Melting point: 165-166 °C(lit.)
Storage temp: -20°C
Solubility: DMSO: soluble
Merck: 3346
InChI
InChI=1/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
Smiles
c12c(c(N3CCCCC3)nc(n2)N(CCO)CCO)nc(N(CCO)CCO)nc1N1CCCCC1
Product Categories: Organics; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; Phosphodiesterase Inhibitors; Cyclic Nucleotide Metabolism; G Proteins and Cyclic Nucleotides; Cyclic Nucleotide related
Toxicity Data With Reference
| 1. | dni-rat:lvr 200 nmol/L | CNREA8 Cancer Research. 43 (1983),1616. | ||
| 2. | oms-rat:lvr 300 nmol/L | CNREA8 Cancer Research. 43 (1983),1616. | ||
| 3. | oms-mus:ast 60 µmol/L | BCPCA6 Biochemical Pharmacology. 22 (1973),2511. | ||
| 4. | orl-man LDLo:1429 µg/kg:CVS | JAMAAP JAMA, Journal of the American Medical Association. 257 (1987),1515. | ||
| 5. | orl-man TDLo:1071 µg/kg:CVS | JAMAAP JAMA, Journal of the American Medical Association. 257 (1987),1515. | ||
| 6. | orl-rat LD50:8400 mg/kg | MEIEDD Merck Index. 10 (1983),489. | ||
| 7. | scu-rat LD50:1650 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 22 (1972),892. | ||
| 8. | ivn-rat LD50:195 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 22 (1972),892. | ||
| 9. | orl-mus LD50:2150 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),848. | ||
| 10. | ipr-mus LD50:150 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD691-490 . |
Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects cardiomyopathy including infarction. Mutation data reported. Used as a coronary vasodilator. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 2
Specification
Dypyridamole , with CAS number of 58-32-2, can be called Ethanol,2,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetra-(6CI,8CI) ; Pyrimido[5,4-d]pyrimidine, ethanol deriv ; 2,2',2'',2'''-[[4,8-Dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl]dinitrilo]tetraethanol ; 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine . It is a yellow powder. Dypyridamole (CAS NO.58-32-2) is commonly used as anti-platelet aggregation drugs,coronary expansion drug for the prevention of recurrent myocardial infarction and angina pectoris, etc.