Basic information
- Name:
Enrofloxacin
- CAS No.:
93106-60-6
- Molecular Structure:
- Formula:
- C19H22FN3O3
- Molecular Weight:
- 359.40
- Synonyms:
- 1-Cyclopropyl-6-fluoro-7-(4-ethyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid;Alsir;BAY-Vp 2674;Baytril;Biofloxavet;CFPQ;Enrocin;Enrofan;Enrogil;Enroxil;N-Ethylciprofloxacin;N'-Ethylciprofloxacin;3-Quinolinecarboxylicacid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-;
- Density:
- 1.385 g/cm3
- Melting Point:
- 225 °C
- Boiling Point:
- 560.5 °C at 760 mmHg
- Flash Point:
- 292.8 °C
- Appearance:
- Pale yellow crystals
- Hazard Symbols:
Xi- Risk Codes:
- 36/37/38
- Safety Description:
- 26-36/37 Details
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Chemistry
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IUPAC Name: 1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxoquinoline-3-carboxylic acid
Molecular Weight: 359.394683 [g/mol]
Molecular Formula: C19H22FN3O3
XLogP3: -0.2
H-Bond Donor: 1
H-Bond Acceptor: 7
Index of Refraction: 1.634
Molar Refractivity: 92.8 cm3
Molar Volume: 259.3 cm3
Surface Tension: 62 dyne/cm
Density: 1.385 g/cm3
Flash Point: 292.8 °C
Enthalpy of Vaporization: 88.7 kJ/mol
Boiling Point: 560.5 °C at 760 mmHg
Vapour Pressure: 2.13E-13 mmHg at 25 °C
Water Solubility: 3400 mg/L at 25 °C
Appearance: Pale Yellow Crystals
Melting Point: 225 °C
Classification Code of Enrofloxacin (CAS NO.93106-60-6): Antibacterial [veterinary]; Antineoplastic agents; Drug / Therapeutic Agent; Mutation data
Product Categories: Antibiotics for Research and Experimental Use; Biochemistry; Quinolones (Antibiotics for Research and Experimental Use); Intermediates & Fine Chemicals; Pharmaceuticals; Veterinaries
Uses
Enrofloxacin (CAS NO.93106-60-6) is widely used in the treatment of human disease. It is a bactericidal agent. The bactericidal activity of enrofloxacin is concentration dependent, with susceptible bacteria cell death occurring within 20-30 minutes of exposure. Enrofloxacin has demonstrated a significant post-antibiotic effect for both Gram-negative and Gram-positive bacteria and is active in both stationary and growth phases of bacterial replication.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 200mg/kg (200mg/kg) | VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987. | |
| mouse | LD50 | oral | 4336mg/kg (4336mg/kg) | VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987. | |
| rabbit | LD50 | oral | 500mg/kg (500mg/kg) | VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987. | |
| rat | LD50 | oral | 5gm/kg (5000mg/kg) | VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987. |
Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS of Enrofloxacin (CAS NO.93106-60-6): VB1993650
Specification
Enrofloxacin (CAS NO.93106-60-6), its Synonyms are 1,4-Dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinolinecarboxylic acid ; 1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ; BAY VP 2674 ; Enrofloxacine ; Enrofloxacino ; 3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo- ; 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo- .