Reference

Cephalosporin preparation for rectal administration

Cephalosporin preparation for rectal administration. Yata, Noboru (Asahi Chemical Industry Co., Ltd., Japan). Eur. Pat. Appl. EP 91502 A1 19 Oct 1983, 38 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: A61K031-545; A61K031-535; A61K009-02. APPLICATION: EP 82-103114 13 Apr 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The absorption of a 3rd-generation cephalosporin [11111-12-9] from the rectum is increased by formulating with an ether-type nonionic surfactant, and the tissue damage from the surfactant is greatly reduced by the addn. of an amino acid to the oleaginous base. A suppository was prepd. contg.There are some commonly used reagents with their cas registry numbers 88285-62-5 and 9005-00-9 in this article. cefotaxime Na [64485-93-4] 5, hydroxylysine-HCl [88285-62-5] 5, polyoxyethylene lauryl ether [9002-92-0] 1, and SB-AM triglyceride base 89% by wt. No rectal damage was found when tested in rats; the incidence of damage without the amino acid was 83.3%. Blood concns. attained in rats given 30 mg cephalosporin/kg were 15 mg/mL at 10 min, and 25 mg/mL at 20 min. .

Further applications of thermoanalytical methods to the detection of potassium and sodium salts of penicillins and cephalosporins

Further applications of thermoanalytical methods to the detection of potassium and sodium salts of penicillins and cephalosporins. Tomassetti, M.; Campanella, L.; Sorrentino, L.; D'Ascenzo, G. (Ist. Chim. Anal., Univ. Studi Roma, Rome, Italy). Thermochim. Acta, 70(1-3), 303-15 (English) 1983. CODEN: THACAS. ISSN: 0040-6031. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Thermogravimetric anal. of antibiotics which decomp. rapidly in air, e.g., cephalosporins and penicillins, was examd. under O and in static air and with and without the addn. of (NH4)2SO4 and (NH4)2S2O8. Thermogravimetric curves of Na and K salts of these antibiotics showed that the decomp. of cephalosporins begins at 135-170° and for penicillins at 160-240°. K benzylpenicillin [113-98-4] under O gave the best results. The accuracy and the precision improved by the addn. of (NH4)2SO4 and (NH4)2S2O8. The addn. of (NH4)2S2O8 was theor. advantageous over that of the (NH4)2SO4, both for lowering the m.p. and for the higher S (%) content. The data obtained with cefuroxime Na [56238-63-2], cefotaxime Na [64485-93-4], and K cephalosporin C [26944-38-7], which decomp. too quickly in O, was not quant. (in O and without any addn. of salt). The compn. of thermal decompn. products (K and Na sulfates) was monitored by IR.