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Basic information

  • Name:
  • Glutaraldehyde

  • CAS No.:
  • 111-30-8

  • Formula:
  • C5H8O2
  • Synonyms:
  • Sterihyde L (TN);Bactrocera oleaeOlive fruit fly is also indexed at this headingBactron K 31;Glutaric dialdehyde;Ucarcide 250;Glutaclean;Ucarcide;Panavirocide;Sonacide;Cidex-Dialyzer;Glutarex 28;Glutaraldehyd;1,5-Pentanedial;Glutaraldehyde Solution BP;Pentanedial;Glutaradehyde;1,5 -Pentanedial; Glutaral; Glutaric dialdehyde;Glutaricdialdehyde;glutaraldehyde(25%、50%);glutaraldehyded 50%;Glutaraldehyde25%;Glutarol;Aldesan;Sterihyde L;1,5-Pentanedione;Glutaric acid dialdehyde;Relugan GT;Sporicidin;Floperm 665X1;1,3-Diformylpropane;Pentanedial;Glutaric aldehyde;Glutaraldehude;
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Chemistry

The Molecular Structure of Glutaraldehyde (CAS NO.111-30-8):

Empirical Formula: C5H8O2
Molecular Weight: 100.1158 
IUPAC Name: pentanedial  
Appearance: Light yellow liquid
Nominal Mass: 100 Da
Average Mass: 100.1158 Da
Monoisotopic Mass: 100.052429 Da 
Index of Refraction: 1.399
Molar Refractivity: 25.58 cm3
Molar Volume: 105.7 cm3
Surface Tension: 30.7 dyne/cm
Density: 0.947 g/cm3
Flash Point: 66 °C
Enthalpy of Vaporization: 42.52 kJ/mol
Boiling Point: 189 °C at 760 mmHg 
Melting point: -5 ºC
Vapour Pressure: 0.583 mmHg at 25°C
Storage temp: 2-8°C
Water Solubility: miscible 
InChI
InChI=1/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
Smiles
C(CC=O)CC=O 
Product Categories: Pharmaceutical Intermediates;INORGANIC & ORGANIC CHEMICALS;Biocide;Alphabetical Listings;Flavors and Fragrances;G-H
Synonyms of Glutaraldehyde (CAS NO.111-30-8): 1,5-Pentanedial.Pentanedial ; Glutardialdehyde ; Glutaric aldehyde ; Glutaric dialdehyde ; Glutaric acid dialdehyde    

Uses

 Glutaraldehyde (CAS NO.111-30-8) is used to disinfect medical and dental equipment. It is also used for industrial water treatment and as a chemical preservative. Besides, it is also used in biological electron microscopy as a fixative and used in SDS-PAGE to fix proteins and peptides prior to staining.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
duck LD50 oral 820mg/kg (820mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)
National Technical Information Service. Vol. OTS0526410-1,
guinea pig LD50 oral 50mg/kg (50mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 77, 1987.
mouse LD50 intraperitoneal 13900ug/kg (13.9mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
mouse LD50 intravenous 15400ug/kg (15.4mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980.
mouse LD50 oral 100mg/kg (100mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980.
mouse LD50 skin > 5840mg/kg (5840mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 11, 1976.
mouse LD50 subcutaneous > 590mg/kg (590mg/kg)   Drugs in Japan Vol. -, Pg. 395, 1995.
rabbit LD50 skin 560uL/kg (0.56mL/kg)   Union Carbide Data Sheet. Vol. 11/4/1971,
rat LC50 inhalation 480mg/m3/4H (480mg/m3)   United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1290-1008,
rat LD50 intraperitoneal 17900ug/kg (17.9mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
rat LD50 intravenous 9800ug/kg (9.8mg/kg)   United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1290-1008,
rat LD50 oral 134mg/kg (134mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980.
rat LD50 skin > 2500mg/kg (2500mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 11, 1976.
rat LD50 subcutaneous > 750mg/kg (750mg/kg)   Drugs in Japan Vol. -, Pg. 395, 1995.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by inhalation, skin contact, and subcutaneous routes. Experimental teratogenic and reproductive effects. A severe eye and human skin irritant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALDEHYDES.
Hazard Codes: ToxicT,HarmfulXn,DangerousN
Risk Statements: 36/37/38-42/43-34-50-23/25-41-20/22 
R36/37/38: Irritating to eyes, respiratory system and skin
R42/43: May cause sensitization by inhalation and skin contact
R34: Causes burns
R50: Very toxic to aquatic organisms
R23/25: Toxic by inhalation and if swallowed
R41: Risk of serious damage to the eyes
R20/22: Harmful by inhalation and if swallowed
Safety Statements: 23-26-45-36/37/39-61 
S23: Do not breathe vapour
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S61: Avoid release to the environment. Refer to special instructions / safety data sheets
RIDADR: UN 2922 8/PG 2
WGK Germany: 3
RTECS: MA2450000
F: 8-10-23
HazardClass: 8
PackingGroup: II

Standards and Recommendations

OSHA PEL: CL 0.2 ppm
ACGIH TLV: CL 0.05 ppm (skin, sensitizer); Not Classifiable as a Human Carcinogen
DFG MAK: 0.1 ppm (0.42 mg/m3)

Analytical Methods

For occupational chemical analysis use OSHA: #ID-64 or NIOSH: Glutaraldehyde 2531.

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