Basic information
- Name:
L-Glutamine
- CAS No.:
56-85-9
- Molecular Structure:

- Formula:
- C5H10N2O3
- Synonyms:
- (S)-2,5-Diamino-5-oxopentanoic acid;Glutamine (VAN);L-Glutamid;Glutamine (USP);(2S)-2-amino-4-carbamoylbutanoic acid;(2S)-2-amino-4-carbamoyl-butanoic acid;L-2-Aminoglutaramic acid;Pentanoic acid, 2,5-diamino-5-oxo-, (S)-;Glutamine [USAN];(2S)-2-azaniumyl-4-carbamoyl-butanoate;Levoglutamina;Cebrogen;Levoglutamidum [INN-Latin];L-(+)-Glutamine;Glumin (amino acid);Levoglutamid;Miglu-P;Levoglutamide [DCF:INN];L-Glutamic acid .gamma.-amide;2-Aminoglutaramic acid;Levoglutamida [INN-Spanish];L-Glutamic acid gamma-amide;Levoglutamide;Glavamin;Glutamic acid 5-amide;(2S)-2,5-diamino-5-oxopentanoic acid;Glutamic acid amide;2,5-Diamino-5-oxopentanoic acid, (S)-;L(+)-Glutamine;L(+)-Glutamic acid-5-amide;H-Gln-OH;Glutamine (P347);Glutamine;L-Glutamine FCC5;L-Gln-OH;L-Glutamine;L-Glutamine FCC4;L-2-Aminoglutaramidic acid;2-Aminoglutaramic acid, L-;L-Glutamic acid 5-amide;2-amino-4-carbamoyl-butanoic acid;
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Chemistry
Molecular Structure:
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Molecular Formula: C5H10N2O3
Molecular Weight: 146.1445
IUPAC Name: (2S)-2,5-Diamino-5-oxopentanoic acid
Synonyms of L-Glutamine (CAS NO.77668-42-9): (S)-2,5-Diamino-5-oxopentanoic acid ; 2,5-Diamino-5-oxopentanoic acid, (S)- ; 2-Aminoglutaramic acid ; 2-Aminoglutaramic acid, L- ; 4-04-00-03038 (Beilstein Handbook Reference) ; AI3-24392 ; BRN 1723797 ; Cebrogen ; EINECS 200-292-1 ; FEMA No. 3684 ; Glavamin ; Glumin ; Glumin (amino acid) ; Glutamic acid 5-amide ; Glutamic acid amide ; Glutamine ; Glutamine (VAN) ; L-(+)-Glutamine ; L-2-Aminoglutaramidic acid ; L-Glutamic acid gamma-amide ; L-Glutamide ; L-Glutamine [JAN] ; Levoglutamid ; Levoglutamida ; Levoglutamida [INN-Spanish] ; Levoglutamide ; Levoglutamidum ; Levoglutamidum [INN-Latin] ; Miglu-P ; NSC 27421 ; Nutrestore ; Pentanoic acid, 2,5-diamino-5-oxo-, (S)- ; Saforis ; Stimulina ; UNII-0RH81L854J
CAS NO: 77668-42-9
Classification Code: Dietary supplement ; Drug / Therapeutic Agent ; Human Data ; Mutation data
Melting Point: 185 °C
Index of Refraction: 1.524
Molar Refractivity: 33.83 cm3
Molar Volume: 110.5 cm3
Surface Tension: 64.5 dyne/cm
Density: 1.321 g/cm3
Flash Point: 223.3 °C
Enthalpy of Vaporization: 77.13 kJ/mol
Boiling Point: 445.6 °C at 760 mmHg
Vapour Pressure: 3.5E-09 mmHg at 25°C
Uses
1. L-Glutamine (CAS NO.77668-42-9) has been studied extensively over the past 10–15 years and has been shown to be useful in treatment of serious illnesses, injury, trauma, burns, cancer and its treatment related side-effects as well as in wound healing for postoperative patients.
2. Glutamine is also marketed as a supplement used for muscle growth in weightlifting, bodybuilding, endurance, and other sports.
3. Glutamine has also been taken to enhance brain function as it fuels two of the brain's most important neurotransmitters.
4. It has also been used in the treatment of ADHD, anxiety,and depression.
5. It has also been used in recovery programs to break sugar craving cycles in alcoholics and assist diabetics in the management of sugar cravings.
6. It is also used as an anti-inflammatory in the treatment of autoimmune diseases and preserves Glutathione levels in the liver.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 27mg/kg/1W-I (27mg/kg) | BEHAVIORAL: EUPHORIA | American Journal of Psychiatry. Vol. 141, Pg. 1302, 1984. |
| mouse | LD50 | oral | 21700mg/kg (21700mg/kg) | Drugs in Japan Vol. 6, Pg. 228, 1982. | |
| rat | LD50 | oral | 7500mg/kg (7500mg/kg) | Drugs in Japan Vol. 6, Pg. 228, 1982. |
Consensus Reports
L-Glutamine (CAS NO.77668-42-9) is reported in EPA TSCA Inventory.
Safety Profile
Hazard Codes L-Glutamine (CAS NO.77668-42-9): Xi 
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-24/25-36/37/39-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S24/25: Avoid contact with skin and eyes.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S27: Take off immediately all contaminated clothing.
WGK Germany: 2
RTECS: MA2275100
HS Code: 29241900
Mildly toxic by ingestion. Human systemic effects: euphoria. When heated to decomposition it emits toxic fumes of NOx.
Specification
1. Fire Fighting Measures
Information of L-Glutamine (CAS NO.77668-42-9): As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
2. Handling and Storage
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container.
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