Basic information
- Name:
Methylparaben
- CAS No.:
99-76-3
- Molecular Structure:
- Formula:
- C8H8O3
- Molecular Weight:
- 152.16
- Deleted CAS:
- 156291-94-0
- Synonyms:
- Methyl parahydroxybenzoate (JP14);Methylester kyseliny p-hydroxybenzoove [Czech];Sodium 4-carbomethoxyphenolate;Sodium methyl p-hydroxybenzoate;Methyl p-oxybenzoate;Methyl ester of p-hydroxybenzoic acid;Methyl parahydroxybenzoate;p-Carbomethoxyphenol;Benzoic acid,4-hydroxy-,esters,methyl ester;Preserval M;Methylparaben (TN);Methylparaben sodium [USAN];Sodium, (p-carboxyphenoxy)-, methyl ester (7CI);p-Oxybenzoesauremethylester [German];Methyl-4-hydroxybenzoate;methylparaben;methyl paraben; methyl p-hydroxybenzoate;methyl para-hydroxybenzoate;Methyl p-Hydroxybenzoate(Methyl paraben);Methyl-p-hydroxybenzoate;p-Methoxycarbonylphenol;Methyl chemosept;4-Hydroxybenzoic acid, methyl ester;Methyl p-hydroxybenzoate, sodium salt;EPA Pesticide Chemical Code 061201;Methyl Butex;p-Hydroxybenzoic acid, methyl ester;component of Heb-Cort MC;Benzoic acid, p-hydroxy-, methyl ester;Methylparaben [USAN];Benzoic acid, 4-hydroxy-, methyl ester;sodium 4-methoxycarbonylphenolate;p-Hydroxybenzoic methyl ester;4-(Methoxycarbonyl)phenol;p-Hydroxybenzoic acid methyl ester;
- EINECS:
- 202-785-7
- Density:
- 1.209 g/cm3
- Melting Point:
- 125-128 °C(lit.)
- Boiling Point:
- 265.5 °C at 760 mmHg
- Flash Point:
- 116.4 °C
- Appearance:
- white crystalline powder
- Hazard Symbols:
Xi,
Xn- Risk Codes:
- 36/37/38-20/21/22
- Safety Description:
- 26-36-24/25 Details
- Transport Information:
- UN 2769
Famous Chemical Enterprises
-
Livzon -
Total -
Shell -
Dupont -
Exxonmobil -
Akzonobel -
Basf -
Bayer -
BP
Please post your buying leads,so that our qualified suppliers will soon
contact you!
*Required Fields
Chemistry
.jpg)
IUPAC Name: Methyl 4-hydroxybenzoate
Molecular Formula: C8H8O3
Formula Weight: 152.15 g/mol
EINECS: 202-785-7
Index of Refraction: 1.547
Molar Refractivity: 39.9 cm3
Molar Volume: 125.7 cm3
Surface Tension: 45.7 dyne/cm
Density: 1.209 g/cm3
Flash Point: 116.4 °C
Enthalpy of Vaporization: 52.38 kJ/mol
Melting point: 125-128 °C(lit.)
Storage tempreture: 0-6 °C
Appearance: White crystalline powder
Boiling Point: 265.5 °C at 760 mmHg
Vapour Pressure: 0.00555 mmHg at 25 °C
Product Category of Methylparaben (CAS NO.99-76-3): Aromatic Esters;Antioxidant;Biochemistry;Color Former & Related Compounds;Developer;Functional Materials
Uses
Methylparaben (CAS NO.99-76-3) is known to slow Drosophila growth rate in the larval and pupal stages. It is an antifungal that is widely used as a preservative for food, drugs, and cosmetics. Mycocten, and is commonly used as an anti-fungal agent in Drosophila food media.Methylparaben is an anti-fungal agent often used in hair gels. The compound is often found in carpules of local anaesthetic, acting as a bacteriostatic agent and preservative. Methylparaben (also called Nipigin M, Tegosept, and Mycocten) is commonly used as a fungicide in Drosophila food media. Usage of methylparaben is known to slow Drosophila growth rate in the larval and pupal stages.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | oral | 3gm/kg (3000mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. | |
| mouse | LD50 | intraperitoneal | 960mg/kg (960mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956. |
| mouse | LD50 | oral | > 8gm/kg (8000mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: ATAXIA | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956. |
| mouse | LD50 | subcutaneous | 1200mg/kg (1200mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 135, 1960. | |
| rabbit | LD50 | oral | 6gm/kg (6000mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. | |
| rat | LD50 | subcutaneous | > 500mg/kg (500mg/kg) | Clinical Toxicology. Vol. 4(2), Pg. 185, 1971. |
Safety Profile
Hazard Codes: 
Xi,
Xn
Risk Statements: 36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RTECS: DH2450000
Specification
Methylparaben , its cas register number is 99-76-3. It also can be called Methyl paraben ; Methyl p-hydroxybenzoate ; 4-(Methoxycarbonyl)phenol ; 4-(Carbomethoxy)phenol ; Methyl Parasept ; Methyl Butex ; Methaben; Metaben ; Methyl 4-hydroxybenzoate ; and 4-Hydroxybenzoic acid methyl ester . Methylparaben (CAS NO.99-76-3) is readily absorbed from the gastrointestinal tract or through the skin. It is hydrolyzed to p-hydroxybenzoic acid and rapidly excreted without accumulation in the body. In a population with normal skin, methylparaben is practically non-irritating and non-sensitizing; however, allergic reactions to ingested parabens have been reported. It can be found in many of the leading skin/face products.