Basic information
- Name:
Pyrazinamide
- CAS No.:
98-96-4
- Molecular Structure:
- Formula:
- C5H5N3O
- Molecular Weight:
- 123.11 .
- Synonyms:
- Pyrazinamide (TN);Pirazinamid;Pirazimida;D-50;T 165;Novamid;NCI-C01785;Pyrazineamide;MK 56;2-Carbamylpyrazine;D-50 (VAN);Pirazinamida [INN-Spanish];Pirazinamide [DCIT];PZA;2-Pyrazinecarboxamide;1/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9;Pyrazinamide (JP14/USP);5-25-04-00178 (Beilstein Handbook Reference);Prestwick_811;Zinamide;Pyrazinamidum [INN-Latin];PYZ;Pyrazinecarboxylic acid amide;Aldinamide;Pyrazinamide [BAN:INN:JAN];Unipyranamide;Pyrazinoic acid amide;DRG 0124;Aldinamid;Farmizina;Eprazin;pyrazine-2-carboxamide;Tebrazid;Pyrazine carboxylamide;Pyrazine carboxamide;
- EINECS:
- 202-717-6
- Density:
- 1.301 g/cm3
- Melting Point:
- 189-191 °C(lit.)
- Boiling Point:
- 357.4 °C at 760 mmHg
- Flash Point:
- 169.9 °C
- Solubility:
- 15 mg/mL in water
- Appearance:
- crystalline solid
- Hazard Symbols:
F,
C- Risk Codes:
- 11-34
- Safety Description:
- 22-24/25-45-36/37/39-26-16 Details
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Chemistry
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IUPAC Name: Pyrazine-2-carboxamide
Molecular Formula: C5H5N3O
Molecular Weight: 123.11 g/mol
SMILES: c1(cnccn1)C(N)=O
InChI: InChI=1/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
EINECS: 202-717-6
Classification Code: Anti-Bacterial Agents; Anti-Infective Agents; Antibacterial [tuberculostatic]; Antitubercular agents; Drug / Therapeutic Agent; Human Data; Mutation data; Tumor data
Product Categories: Drug bulk; Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Pyrazines, Pyrimidines & Pyridazines; Antitubercular; Pyrazinamide; Pyrazines; Chloropyrazines, etc.; Amide; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Pyrazines, Pyrimidines & Pyridazines
Index of Refraction: 1.577
Molar Refractivity: 31.36 cm3
Molar Volume: 94.5 cm3
Polarizability: 12.43×10-24 cm3
Surface Tension: 66.4 dyne/cm
Density: 1.301 g/cm3
Flash Point: 169.9 °C
Enthalpy of Vaporization: 60.28 kJ/mol
Boiling Point: 357.4 °C at 760 mmHg
Melting Point: 189-191 °C(lit.)
Water Solubility: 15 mg/mL
Vapour Pressure of Pyrazinamide (CAS NO.98-96-4): 2.74E-05 mmHg at 25 °C
Uses
Pyrazinamide is a drug used to treat tuberculosis. The drug is largely bacteriostatic, but can be bacteriocidal on actively replicating tuberculosis bacteria.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 1680mg/kg (1680mg/kg) | Chemotherapia. Vol. 5, Pg. 39, 1962. | |
| mouse | LD50 | subcutaneous | 2973mg/kg (2973mg/kg) | Drugs in Japan Vol. -, Pg. 1038, 1995. | |
| mouse | LDLo | oral | 3gm/kg (3000mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA | American Review of Tuberculosis. Vol. 70, Pg. 423, 1954. |
| rat | LDLo | oral | 3gm/kg (3000mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA | American Review of Tuberculosis. Vol. 70, Pg. 423, 1954. |
| women | TDLo | oral | 10mg/kg (10mg/kg) | VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION | JAMA, Journal of the American Medical Association. Vol. 127, Pg. 1356, 1997. |
Safety Profile
Hazard Codes: 
F, 
C
Risk Statements: 11-34
R11:Highly flammable.
R34:Causes burns.
Safety Statements: 22-24/25-45-36/37/39-26-16
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S16:Keep away from sources of ignition.
WGK Germany: 3
RTECS of Pyrazinamide (CAS NO.98-96-4): UQ2275000
Specification
Pyrazinamide (CAS NO.98-96-4), its Synonyms are 2-Carbamylpyrazine ; 2-Pyrazinecarboxamide ; Aldinamid ; Aldinamide ; Eprazin ; Farmizina ; Pyrazinecarboxylic acid amide ; Pyrazinoic acid amide ; Tebrazid ; Unipyranamide ; Zinamide . It is white powder.