- Thioridazine
- Thioridazine hydrochloride
- 1306-19-0Cadmium oxide (CdO)
- 13061-96-6Boronicacid, methyl- (9CI)
- 1306-23-6Cadmium sulfide
- 130623-81-34,5-Pyrimidinediamine, 6-chloro-N4,N4-dimethyl-
- 1306-24-7Cadmium selenide (CdSe)
- 130624-89-4Cyclohexaneacetic acid,a-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-,[1(R)-cis]- (9CI)
- 1306-25-8Cadmium telluride(CdTe)
- 13062-76-5Phenol,4-[2-(methylamino)ethyl]-, hydrochloride (1:1)
- 13062-78-7Formamide, N-(p-hydroxyphenethyl)-
- 130628-75-0Isoxazole,3-(bromomethyl)-5-methyl-
Hot Products
- 4771-47-5Benzoicacid, 3-chloro-2-nitro-
- 109-16-02-Propenoic acid,2-methyl-, 1,1'-[1,2-ethanediylbis(oxy-2,1-ethanediyl)] ester
- 316-41-6Berberine sulfate
- 86408-72-21-Phenanthrenecarboxylicacid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-,sodium salt (1;1), (1R,4aS,10aR)-
- 110-93-05-Hepten-2-one,6-methyl-
- 4462-55-94-Isoxazolecarbonylchloride, 3-(2,6-dichlorophenyl)-5-methyl-
- 121848-75-710,10'-Dibromo-9,9'-bianthryl
- 917-23-75,10,15,20-Tetraphenylporphyrin
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
Thioridazine hydrochloride |
EINECS | 204-992-8 |
| CAS No. | 130-61-0 | Density | 1.1227 (rough estimate) |
| PSA | 57.08000 | LogP | 6.69050 |
| Solubility | Soluble in water (75 mM), DMSO (100 mM), chloroform, ethanol, and methanol. | Melting Point |
158-160 °C |
| Formula | C21H27ClN2S2 | Boiling Point | 515.7 °C at 760 mmHg |
| Molecular Weight | 407.044 | Flash Point | 265.7 °C |
| Transport Information | UN 3077 9/PG 3 | Appearance | Pale yellow solid |
| Safety | 26-36-60-61 | Risk Codes | 22-36/37/38-50/53 |
| Molecular Structure |
|
Hazard Symbols |
 Xn,  N
|
| Synonyms |
10H-Phenothiazine,10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride (9CI);Phenothiazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)-,hydrochloride (6CI,7CI);Phenothiazine,10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)-, monohydrochloride (8CI);10-[3-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)phenothiazine hydrochloride;2-Methylmercapto-10-[2-(N-methyl-2-piperidyl)ethyl]phenothiazine hydrochloride;Aldazine;Mallorol;Mellaril;Mellaril hydrochloride;Melleretten;Melleril (tablet);NSC 186060;Novoridazine;Orsanil;Stalleril;10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride;10H-Phenothiazine,10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, hydrochloride (1:1); |
Article Data | 2 |
Thioridazine hydrochloride Synthetic route
- 130-61-0
thioridazine Hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{2-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 50℃; for 18h; Inert atmosphere; Stage #2: With hydrogenchloride In ethanol; water | 100% |
| Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 - 50 °C / Inert atmosphere 2: hydrogenchloride / ethanol; water View Scheme |
- 50-52-2, 52496-67-0, 57129-06-3, 114488-10-7
thioridazine
- 130-61-0
thioridazine Hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In ethanol; water | 100% |
| Conditions | Yield |
|---|---|
| With dihydrogen peroxide In water for 72h; Ambient temperature; | 93% |
- 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester
- 130-61-0
thioridazine Hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: thioridazine Hydrochloride With triethylamine In 1,2-dichloro-ethane at 20℃; for 0.333333h; Inert atmosphere; Stage #2: carbonochloridic acid 1-chloro-ethyl ester In 1,2-dichloro-ethane for 12h; Inert atmosphere; Reflux; | 84% |
- 513-53-1
1-methyl-1-propanethiol
- 130-61-0
thioridazine Hydrochloride
- 96457-89-5
2-(sec-butylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine
| Conditions | Yield |
|---|---|
| With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube; | 71% |
| Conditions | Yield |
|---|---|
| With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube; | 62% |
- 34301-54-7
1-Adamantanethiol
- 130-61-0
thioridazine Hydrochloride
| Conditions | Yield |
|---|---|
| With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube; | 61% |
- 130-61-0
thioridazine Hydrochloride
- 100-53-8
phenylmethanethiol
- 97013-68-8
2-(benzylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine
| Conditions | Yield |
|---|---|
| With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube; | 56% |
| Conditions | Yield |
|---|---|
| In acetonitrile for 24h; Reflux; Inert atmosphere; | 51% |
| Conditions | Yield |
|---|---|
| With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube; | 49% |
Thioridazine hydrochloride Chemical Properties
.jpg)
IUPAC NAME: 10-[2-(1-Methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine hydrochloride
EINECS: 204-992-8
Molecular Formula: C21H27ClN2S2
Molecular Weight: 407.04 g/mol
Flash Point: 265.7 °C
Boiling Point: 515.7 °C at 760 mmHg
Enthalpy of Vaporization: 78.76 kJ/mol
Vapour Pressure: 9.65E-11 mmHg at 25 °C
Appearance: Pale Yellow Solid
Melting Point: 158-160 °C
Product Categories: Miscellaneous ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Dopamine receptor
Classification Code of 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride (CAS NO.130-61-0): Antipsychotic; Drug / Therapeutic Agent; Human Data; Mutation data; Sedative-hypnotic
Thioridazine hydrochloride Uses
10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride (CAS NO.130-61-0) is used for acute schizophrenia, bipolar disorder, menopause, mental illness, nervous depression.
Thioridazine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 160mg/kg (160mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972. | |
| mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| mouse | LD50 | intravenous | 33mg/kg (33mg/kg) | Therapie. Vol. 14, Pg. 793, 1959. | |
| mouse | LD50 | oral | 360mg/kg (360mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972. | |
| rabbit | LD50 | intravenous | 26mg/kg (26mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972. | |
| rabbit | LD50 | oral | 1100mg/kg (1100mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972. | |
| rat | LD50 | intravenous | 71mg/kg (71mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972. | |
| rat | LD50 | oral | 1060mg/kg (1060mg/kg) | Drugs in Japan Vol. 6, Pg. 458, 1982. | |
| women | TDLo | oral | 864mg/kg/18D- (864mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION | Postgraduate Medical Journal. Vol. 60, Pg. 445, 1984. |
Thioridazine hydrochloride Consensus Reports
EPA Genetic Toxicology Program.
Thioridazine hydrochloride Safety Profile
Poison by ingestion and intravenous routes. Human systemic effects: evidence of thyroid hyperfunction, increased body temperature, pulse rate increase. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, SOx, and HCl.
Hazard Codes: 
Xn,
N
Risk Statements:
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S60: This material and its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
Thioridazine hydrochloride Specification
10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride (CAS NO.130-61-0), its Synonyms are Thioridazine hydrochloride ; 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-, monohydrochloride ; 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine hydrochloride ; Mellaril ; Mellaril hydrochloride ; Melleril (tablet) ; Melzine ; Sonapax hydrochloride ; Thioridazine HCl ; Thioridazine chloride .
What can I do for you?
Get Best Price
