Reference

Antioxidative effects of benidipine hydrochloride in patients with hypertension independent of antihypertensive effects: Relationship between blood pressure and oxidative stress

Antioxidative effects of benidipine hydrochloride in patients with hypertension independent of antihypertensive effects: Relationship between blood pressure and oxidative stress. Suzuki, Osamu; Yoshida, Takayuki; Tani, Shigeya; Kato, Kimihiko; Yoneyama, Akihiko; Hibino, Tsuyoshi; Yokoi, Kiyoshi; Matsubara, Tatsuaki (Department of Cardiology, Gifu Prefectural Tajimi Hospital, Gifu, Japan). Arzneimittel Forschung, 54(9), 505-512 (English) 2004 Editio Cantor Verlag. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 14 This study investigated the significance of measuring plasma level of thiobarbituric acid reactive substance (TBARS) in patients with hypertension and compared the clin. effects of benidipine hydrochloride (CAS 91599-74-5, Coniel) and amlodipine besylate (CAS 111470-99-6) on plasma TBARS. At first, blood pressure and plasma TBARS were measured in 85 untreated patients (48 males and 37 females, 68 yr old on av.) with at least one risk factor of cardiovascular disease to investigate factors which had influence on plasma TBARS. As the result, plasma TBARS was significantly higher in those with hypertension, which was also true when adjusted for other factors (r = 0.359, p< 0.01). Among these patients, benidipine hydrochloride at the dose of 4 mg/day was administered to 49 patients with hypertension or angina pectoris. All patients stratified for each factor showed significantly decreased plasma TBARS after benidipine hydrochloride treatment. Second, 40 untreated patients with essential hypertension were randomly assigned to the amlodipine group (5-7.5 mg/day) or benidipine group (4-8 mg/day) to compare the plasma TBARS levels. Plasma TBARS levels were significantly decreased in both groups. The amlodipine group showed a pos. correlation between the decrease in plasma TBARS level and those in both diastolic and systolic blood pressures after treatment. On the other hand, benidipine hydrochloride decreased plasma TBARS to a greater degree than both diastolic and systolic blood pressures. These findings suggest that patients with hypertension have high plasma TBARS, and benidipine hydrochloride decreases not only blood pressure but also oxidative stress in the clin. practice.

Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats

Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. Choi, Seul Min; Kim, Jee Eun; Ahn, Byoung Ok; Kwon, Jong Won ( Research Laboratories, Dong-A Pharmaceutical Company, Kyunggi-do, S. Korea). Arzneimittel Forschung, 56(1), 12-17 (English) 2006 Editio Cantor Verlag. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Hypertension is a common problem in elderly patients, which usually requires chronic therapy under various physiol. conditions including low gastric acidity (hypo- or anacidity). This study investigated a new salt type of amlodipine (CAS 88150-42-9) on blood pressure and hypertension-related complications in stroke-prone spontaneously hypertensive rats (SHR-SP). Amlodipine orotate was prepd. by reacting orotic acid and amlodipine to increase the dissoln. rate at higher gastric pH conditions. Twelve-week-old SHR-SP were randomly divided into five groups to receive either amlodipine orotate or amlodipine besylate (CAS 111470-99-6) at the doses of 3 and 10 mg/kg/day orally for four weeks. The age-matched normotensive Wistar Kyoto rats (WKY) served as the normal pos. control group. The systolic blood pressure was reduced in the amlodipine treated SHR-SP in a dose-dependent manner with a similar potency irresp. of the salt type. Both amlodipines also reduced the left ventricular hypertrophy at high doses and concn.-dependently inhibited the Ca2+-induced contraction with a similar potency. Furthermore, semi-quant. anal. of a cerebral injury revealed that the two salts of amlodipine reduced the stroke-related lesions to a similar degree. These results suggest that the amlodipine orotate is effective in terms of its effects on hypertension, cardiac hypertrophy and stroke-related cerebral damage in SHR-SP.