Detail of "121-60-8"

CAS Number:
121-60-8
Name:
N-Acetylsulfanilyl chloride
Molecular Structure:
Formula:
C₈H₈ClNO₃S
Molecular Weight:
233.67 .
Synonyms:
4-Acetamidobenzene sulfonyl chloride;4-(Acetylamino)phenylsulfonyl chloride;4-Acetamidobenzene-1-sulfonyl chloride;4-Chlorosulfonylacetanilide;4'-(Chlorosulfonyl)acetanilide;Benzenesulfonylchloride, 4-(acetylamino)-;Acetanilide-p-sulfonyl chloride;Dagenan chloride;N-(4-Chlorosulfonylphenyl)acetamide;N-Acetyl-p-aminobenzenesulfonyl chloride;p-(Chlorosulfonyl)acetanilide;p-Acetamidobenzenesulfonyl chloride;
EINECS:
204-485-1
Density:
1.468 g/cm³
Melting Point:
142-145 ºC
Boiling Point:
426.8 ºC at 760 mmHg
Flash Point:
211.9 ºC
Solubility:
Slightly soluble in water
Appearance:
off-white to slightly grey granular cryst powder
Hazard Symbols:
C
Risk Codes:
22-34-37
Safety:
26-36/37/39-45-28B Details
Transport Information:
UN 3261 8/PG 2

New aminopyrimidinonic derivatives with potential biological activity: New aminopyrimidinonic derivatives with potential biological activity. Mager, Sorin; Cristea, I.; Craciun, Liliana; Irimie, F.; Diudea, M. (Dep. Org. Chem., "Babes-Bolyai" Univ., Cluj-Napoca, Rom.). Rev. Roum. Chim., 36(4-7), 665-70 (English) 1991. CODEN: RRCHAX.Several substances with their cas registry numbers 141077-04-5 and 121-60-8 may be metioned in this study. ISSN: 0035-3930. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 5 Aminopyrimidinone I (R = NH2) (II), a byproduct in the industrial synthesis of the fungicide ethyrimol from ethylguanine nitrate and butylacetoacetate, was transformed into a variety of derivs. Thus, reaction of II with acid chlorides gave amides and sulfonamides I (R = NHBz, NHCOCH2C6H4Cl-4, NHCOCH2C6H4Me-2, NHSO2C6H4Me-4, NHSO2C6H4NHR1; R1 = Ac, H). Hydroxy and chloro derivs. I (R = OH, Cl) were prepd. via diazotization of II, and the corresponding urea deriv. was prepd. by reaction of II with COCl2. I (R = NHCOCH2C6H4Cl-4, NHCOCH2C6H4Me-2) show significant auxinic activity and a lack of toxicity. .

Preparation of arylsulfonamides for use in pharmaceuticals and cosmetics: Preparation of arylsulfonamides for use in pharmaceuticals and cosmetics. Barthell, Eduard; Schmid, Otto (Fed. Rep. Ger.). Ger. Offen. DE 3528992 A1 26 Feb 1987, 3 pp. (Germany) CODEN: GWXXBX. CLASS: ICM: C07C143-80. ICS: A61K031-63; A61K007-40.Several reagents with their cas registry numbers 121-60-8 and 107611-38-1 are used here. APPLICATION: DE 85-3528992 13 Aug 1985. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 62, 63 The title compds. I and II (R1, R2 = H, halo; R3 = H, alkali metal, etc.; X = CH:CH, CH2CH2), useful in cosmetics and pharmaceuticals, are prepd. An aq. soln. contg. 227 g disulfonic acid III and 60 g CaCO3 was treated with 257 g 4-AcNHC6H4SO2Cl and the resulting product (205 g) was added to an aq. soln. contg CaCO3 and then treated with 200 g 3,4-Cl2C6H3SO2Cl to give 77% I (R1 = R2 = Cl, R3 = Na, X = CH:CH). A general skin cream was formulated contg. 2 g of title compd. in 98 g of an oil-water emulsion. .