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CAS No.: | 123-99-9 |
---|---|
Name: | Azelaic acid |
Article Data: | 309 |
Molecular Structure: | |
Formula: | C9H16O4 |
Molecular Weight: | 188.224 |
Synonyms: | 1, 9-Nonanedioic acid;Nonanedioic acid;Azelaic acid, technical grade;Lepargylic acid;Heptanedicarboxylic acid;Nonanedioic acid Azelaic acid;Empol 1144;1,7-Heptanedicarboxylic acid;Emerox 1144;Emerox 1110;Ammonium Hydrogen Azelate;Azelaic Acid 99%; |
EINECS: | 204-669-1 |
Density: | 1.131 g/cm3 |
Melting Point: | 98-103 ºC |
Boiling Point: | 370.5 ºC at 760 mmHg |
Flash Point: | 192.1 ºC |
Solubility: | warer: 2.4 g/L (20 °C) |
Appearance: | white to cream solid |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 24/25-36-26 |
PSA: | 74.60000 |
LogP: | 1.88630 |
Conditions | Yield |
---|---|
With phosphotungstic acid; potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride; dihydrogen peroxide; oxygen at 95℃; for 8h; Reagent/catalyst; Concentration; Temperature; | 99.23% |
With potassium permanganate | 80% |
With oleate hydratase from S. maltophilia In aq. buffer at 35℃; for 2h; pH=8; Enzymatic reaction; | 21% |
Conditions | Yield |
---|---|
With 1 wt% Au/Al2O3; oxygen; sodium hydroxide In water at 80℃; under 3750.38 Torr; for 4.33333h; Autoclave; Inert atmosphere; | A 86% B 99% |
With copper(II) ferrite; oxygen In neat (no solvent) at 80℃; under 18751.9 Torr; for 5h; Reagent/catalyst; Temperature; Pressure; Autoclave; | A 57.24% B 46.65% |
With sodium stannate; dihydrogen peroxide; tungsten(VI) oxide In water; tert-butyl alcohol at 130℃; for 4h; Sealed tube; |
Conditions | Yield |
---|---|
With sodium periodate; RuCl3*2.9H2O In water at 20℃; for 8h; Sonication; | A 62% B 98% |
With dihydrogen peroxide In tert-butyl alcohol at 85℃; for 3.5h; Catalytic behavior; Reagent/catalyst; |
Conditions | Yield |
---|---|
With potassium permanganate; sodium hydroxide In water at 50℃; for 8h; Reagent/catalyst; Temperature; | A 96% B 81% |
With oxygen; ozone In water; acetone at 0℃; for 0.333333h; Reagent/catalyst; Solvent; Temperature; Flow reactor; | A 89% B 74% |
With cetylpyridinium peroxotungstophosphate; dihydrogen peroxide In water at 80℃; for 1h; | A 86% B 82% |
dec-9-enoic acid
azelaic acid
Conditions | Yield |
---|---|
With sodium periodate; RuCl3*2.9H2O In water at 20℃; for 0.5h; Sonication; | 96% |
With dihydrogen peroxide; cetyltrimethylammonim bromide; ortho-tungstic acid at 50 - 77℃; Inert atmosphere; | 76% |
Conditions | Yield |
---|---|
With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In water; acetonitrile at 20℃; for 8h; Reagent/catalyst; Solvent; Temperature; | 94% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In tetrahydrofuran at 23℃; for 120h; | A n/a B 2% C 92% |
With sodium tetrahydroborate In tetrahydrofuran at 65℃; for 6h; | A n/a B 6% C 87% |
8-cyano-octanoic acid
azelaic acid
Conditions | Yield |
---|---|
With sulfuric acid at 100℃; for 6h; | 90% |
With sulfuric acid at 100℃; for 6h; | 90% |
In anhydrous ethylene glycol dimethyl ether | |
In sulfuric acid |
Conditions | Yield |
---|---|
With water for 48h; Rhodococcus rhodochrous AJ270; | 88% |
With potassium phosphate buffer; Rhodococcus sp. AJ270 at 30℃; for 48h; | 88% |
The Molecular Structure of Azelaic acid (CAS NO.123-99-9):
Empirical Formula: C9H16O4
Molecular Weight: 188.2209
IUPAC Name: nonanedioic acid
Appearance: white to cream solid
Nominal Mass: 188 Da
Average Mass: 188.2209 Da
Monoisotopic Mass: 188.104859 Da
Index of Refraction: 1.475
Molar Refractivity: 46.87 cm3
Molar Volume: 166.3 cm3
Surface Tension: 46.2 dyne/cm
Density: 1.131 g/cm3
Flash Point: 192.1 °C
Enthalpy of Vaporization: 67.8 kJ/mol
Boiling Point: 370.5 °C at 760 mmHg
Vapour Pressure: 1.66E-06 mmHg at 25°C
Water Solubility: 2.4 g/L (20 °C)
Stability: Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days
Product Categories: API intermediates;alpha,omega-Alkanedicarboxylic Acids;alpha,omega-Bifunctional Alkanes;Monofunctional & alpha,omega-Bifunctional Alkanes
InChI
InChI=1/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
Smiles
C(CCCCCCCC(O)=O)(O)=O
Azelaic acid (CAS NO.123-99-9) can be used as plasticizers, and used in the synthesis of alkyd resin, paint and other chemicals.
1. | skn-rbt 500 mg/24 H MLD | EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) S3B,- ,1964. | ||
2. | eye-rbt 3 mg MLD | EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) S3B,- ,1964. | ||
3. | orl-rat LD50:>5 g/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD-A067-313 . |
Reported in EPA TSCA Inventory.
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 24/25-36-26
S24/25: Avoid contact with skin and eyes
S36: Wear suitable protective clothing
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany: 1
RTECS: CM1980000
HS Code: 29171390
Low toxicity by ingestion. A skin and eye irritant. Closely related to glutaric acid and adipic acid. Combustible when exposed to heat or flame; can react with oxidizing materials.
For occupational chemical analysis use NIOSH: Azelaic Acid , 5019.
Azelaic acid (CAS NO.123-99-9) is also called as Azelaic acid [USAN:INN] ; 1,7-Heptanedicarboxylic acid ; 1,9-Nonanedioic acid ; Acide azelaique ; Acide azelaique [French] ; Acidum azelaicum ; Azelaic acid, technical grade ; Heptanedicarboxylic acid ; Nonanedioic acid .