Reference

9-Oxime macrolide antibacterials

9-Oxime macrolide antibacterials. Searle, Xenia Beebe; Djuric, Stevan; Ma, Zhenkun; Yang, Fan (USA ). U.S. Pat. Appl. Publ. US 2004014691 A1 22 Jan 2004,18 pp. (English). (United States of America). CODEN: USXXCO. CLASS: ICM: C07H017-08. ICS: A61K031-7048. NCL: 514029000; 536007400. APPLICATION: US 2003-420391 22 Apr 2003. PRIORITY: US 2002-PV375361 25 Apr 2002. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 10, 26 Antibacterial compds. I (R1 = alkyl, (CH2)alkenyl, (CH2)alkynyl, etc.; R2 = H, alkyl, (CH2)alkenyl, (CH2)alkynyl, etc.; R3 = H, hydroxyl protecting group; one of R4 and R5 = H and the other = OH; or R4 and R5 = =O; X1 = H, F) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compds. and intermediates used in the processes, compns. contg. 75-18-3 and 133745-75-2 which are cas registry numbers of chemicals are mentioned. the compds., and methods for prophylaxis or treatment of bacterial infections using the compds. are disclosed. Compds. displayed antibacterial activity of 0.008-128 mg/mL against Staphylococcus aureus, Streptococcus pyogenes, S. pneumoniae, Enterococcus faecalis, E. faecium, Moraxella catarrhalis, Haemophilus influenzae, and Escherichia coli. .