Reference

Controlled-release penicillin complexes: dissolution and stability of benzathine cloxacillin

Controlled-release penicillin complexes: dissolution and stability of benzathine cloxacillin. Irwin, W. J.; Hempenstall, J. M.; Po, A. Li Wan; Andrews, A. H. (Dep. Pharm., Univ. Aston, Birmingham B4 7ET, UK). Int. J. Pharm., 20(1-2), 25-41 (English) 1984. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 22 The dissoln. behavior of benzathine cloxacillin (I benzathine salt) [23736-58-5] is dependent upon pH. At pH 6.0, dissoln. is governed by the soly. product of the complex and steady-state conditions are achieved. The degrdn. rate of I [61-72-3] becomes significant when dissoln. is undertaken at pH 2.0. This prevents maintenance of the equil. concn. of I and as time proceeds the soln. contains an increasing proportion of benzathine [140-28-3]. At pH 9.0 I continues to degrade a first-order process but, addnl., a bimol. reaction involving benzathine and I produces an amide adduct (II) [92745-21-6]. This product results in the loss of benzathine from soln. and eventually appears as a ppt.

Synthesis of N,N'-dibenzylethylenediamine diacetate

Synthesis of N,N'-dibenzylethylenediamine diacetate. Experimental data. Yurevich, V. P.; Khlyupina, L. E.; Shul'gina, N. L.; Noskova, T. A. (Usol'e-Sib. Khim.-Farm. Komb., Usole-Sibirskoe, USSR). Khim.-Farm. Zh., 17(10), 1247-8 (Russian) 1983. CODEN: KHFZAN. ISSN: 0023-1134. DOCUMENT TYPE: Journal CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Benzylating H2NCH2CH2NH2 with PhCH2Cl (I) in 0..003 ratio at 50° in aq.There are some commonly used reagents with their cas registry numbers 140-28-3 and 122-75-8 in this article. NaOH gave PhCH2NHCH2CH2NH2 (II) and Ph(CH2NHCH2)2Ph (III). Treating II with I in 0..156 ratio as above gave III, which gave 34.51% title compd. with AcOH in Me2CO. .