Detail of "177834-92-3"

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Validation of an HPLC method for the simultaneous determination of eletriptan and UK 120

All Rights Reserved. Validation of an HPLC method for the simultaneous determination of eletriptan and UK 120.413. Zecevic, Mira; Jocic, Biljana; Agatonovic-Kustrin, Snezana; Zivanovic, Ljiljana (Faculty of Pharmacy, Institute of Pharmaceutical Chemistry and Drug Analysis, Belgrade 11000, ). Journal of the Serbian Chemical Society, 71(11), 1195-1205 (English) 2006 Serbian Chemical Society. CODEN: JSCSEN. ISSN: 0352-5139. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 80 A rapid and sensitive RP HPLC method was developed for the routine control anal. of electriptan hydrobromide and its org. impurity UK 120.413 in Relpax tablets. The chromatog. was performed at 20° using a C18 XTerra (5 mm, 150 ′ 4,6 mm) column at a flow rate 1.0 mL/min. The drug and its impurity were detected at 225 nm. The mobile phase consisted of TEA (1%)-methanol (67.2:32.8 vol./vol.), the pH of which was adjusted to 6.8 with 85 % H3PO4. Quantification was accomplished by the internal std. method. The developed RP-HPLC method was validated by testing: accuracy, precision, repeatability, specificity, detection limit, quantification limit, linearity, robustness, and sensitivity.Several substances with their cas registry numbers 177834-92-3 and 209682-64-4 may be metioned in this study. High linearity of the anal. procedure was confirmed over the concn. range of 0.05-1.00 mg/mL for eletriptan hydrobromide and from 0.10-1.50 mg/mL for UK 120.413, with correlation coeffs. greater than r = 0.995. The low value of the RSD expressed the good repeatability and precision of the method. Exptl. design and a response surface method were used to test robustness of the anal. procedure and to evaluate the effect of variation of the method parameters, namely the mobile phase compn., pH, and temp. They showed small deviations from the method setting. The good recovery and low RSD confirm the suitability of the proposed RP HPLC method for the routine detn. of eletriptan hydrobromide and its impurity UK 120.413 in Relpax tables. .

New drugs in 2002

New drugs in 2002. Vervaeren, Jacques (Service Scientifique A.P.B., Fr.). Journal de Pharmacie de Belgique, 57(3), 45-70 (French) 2002 Association Pharmaceutique Belge, Service Scientifique. CODEN: JPBEAJ. ISSN: 0047-2166. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review on the pharmacol. 177834-92-3 and 28721-07-5 are just another two chemicals used in this study. of Trileptal, Relert, Aerius, Xyzall, Actos, Avelox, and NovoRapid. .