Reference

Stabilized solid choline salicylate mixtures

Stabilized solid choline salicylate mixtures. Sasmor, Ernest J. (Mundipharma A.-G., Switz.). Ger. Offen. DE 2701553 28 Jul 1977, 27 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C08B015-00. PRIORITY: US 76-651110 21 Jan 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Complexes of choline salicylate (I) [2016-36-6], carboxymethyl cellulose [9000-11-7], and divalent metal ions are prepd. In contrast to I, the complexes are not hygroscopic, are stable for ￡4 years, and can be made into tablets. For example, an aq. soln. of 90% I was mixed with an equimolar amt. of anhyd. aluminum hydroxy salicylate, and 2.5-25% (of the total wt.) I was added. The compn. was hardened and ground to give a stable, dry, free-flowing powder. The powder ws compressed with additives into tablets each contg. 435 mg I.

Evaluation of drug bioavailability under clinical conditions

Evaluation of drug bioavailability under clinical conditions. Cepelak, V.; Mayer, O.; Cepelakova, H.; Vitous, J.; Petrlik, M. (Dep. Clin. Pharmacol., Fac. Hosp., Plzen, Czech.). Zentralbl. Pharm., Pharmakother. Laboratoriumsdiagn., 116(4), 345-53 (German) 1977. CODEN: ZPPLBF. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Serum levels of trimethazone [13221-27-7] (500 mg orally, i.m. or i.v.), ketazone [853-34-9] (500 mg in aq. and nonaq. solns., i.m.), xanthinol nicotinate [437-74-1] (1500 mg as xanidil or complamin, i.v.), salicylate (as arthropan [2016-36-6], acylpyrin [50-78-2], Syrap [2016-36-6], or choline salicylate [2016-36-6]) and several tribenoside [10310-32-4] prepns. or jaritin [37750-83-7] were compared in rats or man. Bioavailability was affected by drug form and administration route.