Reference

Metabolic studies of hydroxyzine and meperidine in human subjects

Metabolic studies of hydroxyzine and meperidine in human subjects. Stambaugh, John E.; Wainer, Irving W. (Dep. Pharmacol.Chemicals with cas numbers 77-17-8 and 57-42-1 also play role., Thomas Jefferson Univ., Philadelphia, Pa., USA). Adv. Pain Res. Ther., Volume Date 1975, 1(World Congr. Pain 1st.), 559-65 (English) 1976. CODEN: APRTDE. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In normal volunteers, hydroxyzine-HCl (I-HCl) [2192-20-3] did not affect the metab. of meperidine (II) [57-42-1], esp. the rate of N-demethylation, as indicated by the urinary excretion of II and normeperidine [77-17-8]. Thus, I does not potentiate the analgesic effect of II by altering its metab. .

A comparison of droperidol, diazepam, and hydroxyzine hydrochloride as premedication

A comparison of droperidol, diazepam, and hydroxyzine hydrochloride as premedication. Tornetta, Frank J. (Dep. Anesthesiol., Montgomery Hosp., Norristown, Pa., USA). Anesth. Analg. (Cleveland), 56(4), 496-500 (English) 1977. CODEN: AACRAT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A double-blind comparison of the effiacy and safety of droperidol [548-73-2] (5 mg), hydroxyzine-HCl [2192-20-3] (50 mg), diazepam [439-14-5] (5 mg), and saline placebo, given concomitantly with meperidine (50 or 75 mg) for preoperative medication, was conducted in 280 female patients scheduled for minor gynecol. procedures. Droperidol was superior to the other drugs in alleviating apprehension (83% of patients calm vs. 54, 46, and 34% for hydroxyzine, diazepam, and placebo, resp.). Some drowsiness occurred in 68% of the droperidol-treated patients vs. 31, 30, and 21 percent of the other 3 groups, resp. No clin. significant changes were obsd. in vital signs in any of the study-drug groups. Adverse reactions were unremarkable in all groups. Significantly less nausea occurred with droperidol than with the other treatments, and significantly less vomiting occurred with droperidol or hydroxyzine. Significantly fewer patients in the droperidol group than in the diazepam group required postoperative antiemetics.