Reference

In vitro absorption studies on naproxen and its sodium and piperazine salts

In vitro absorption studies on naproxen and its sodium and piperazine salts. Zecchi, V.; Rodriguez, L.; Tartarini, A.; Chiarini, A.; Valenti, P. (Fed. Rep. Ger.). Pharm. Acta Helv., 59(3), 91-4 (English) 1984. CODEN: PAHEAA. ISSN: 0031-6865. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 The dissoln. and partition of naproxen (I) [22204-53-1], naproxen Na (II) [26159-34-2], and naproxen 2-piperazineethanol (III) [90294-25-0] were examd. in a 3 phase partition system of water-octanol-water at pH 2, 6. 22204-53-1 and 90294-25-0 are cas registry numbers of chemicals which are used as reagents here.5, and 8. At each pH value of the releasing phase the dissoln. follows the decreasing order II > III > I. Dissoln. profiles (concns. in the receiving phase vs. time) at each pH were linear. The different dissoln. rates for I and its Na and piperazine salts indicates that the dissoln. rate represents the limiting factor in the bioavailability of I in solid dosage form. .

X-ray powder diffraction data for selected drugs: furosemide, hydrochlorothiazide, naproxen, naproxen sodium, propranolol hydrochloride, and the halopheniramine maleates

X-ray powder diffraction data for selected drugs: furosemide, hydrochlorothiazide, naproxen, naproxen sodium, propranolol hydrochloride, and the halopheniramine maleates. De Camp, Wilson H. (Div. Drug Chem., Food and Drug Adm., Washington, DC 20204, USA). J. Assoc. Off. Anal. Chem., 67(5), 927-33 (English) 1984. CODEN: JANCA2. ISSN: 0004-5756. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63, 75 X-ray powder diffraction data for furosemide [54-31-9], hydrochlorothiazide [58-93-5], propranolol-HCl [318-98-9], (±)- [7054-11-7] and (+)-chlorpheniramine maleate [2438-32-6], (+)- [2391-03-9] and (±)-brompheniramine maleate [32865-01-3], naproxen [22204-53-1], and naproxen Na [26159-34-2] are reported. The data for furosemide, hydrochlorothiazide, propranolol-HCl, (+)-chlorpheniramine maleate, and brompheniramine maleate are indexed by ref. to published crystal structure data. The racemic modifications of propranolol-HCl and brompheniramine maleate exist as racemic compds. rather than racemic mixts. The data are sufficient for identification of the drugs in the pure bulk form and in dosage forms if excipients are absent or do not overlap the main d spacings.