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Detail of "56391-57-2"

  • CAS Number:
  • 56391-57-2
  • Name:

  • Netilmicin sulfate

  • Molecular Structure:
  • Formula:
  • C21H41N5O7.2.5(H2SO4)
  • Molecular Weight:
  • 720.80
  • Synonyms:
  • Netilmicinum [INN-Latin];Netilmicin sulfate [USAN:JAN];Netillin;(2R,3R,4R,5R)-2-[(1S,2R,3R,4S,6R)-4-amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-ethylamino-2-hydroxy-cyclohexyl]oxy-5-methyl-4-methylamino-oxane-3,5-diol;56391-56-1;Neomycin Trisulfate;Nelitmicin sulfate;Netilmicin Sulfate Sterile and non-sterile;Sch-20569;D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl(1-4))-2-deoxy-N(sup 1)-ethyl-;Netilmicin sulphate;1-N-Aethylsisomicin;Nettacin;NTL;Certomycin;Zetamicin;Netromycin (TN);Vectacin;Netilyn;NTL sulfate;Netilmicine [INN-French];
  • EINECS:
  • 260-147-3
  • Density:
  • 1.32 g/cm3
  • Boiling Point:
  • 684.3 °C at 760 mmHg
  • Flash Point:
  • 367.7 °C
  • Solubility:
  • Easily soluble in water, almost insoluble in alcohol or ether
  • Appearance:
  • white to light yellow powder
  • Hazard Symbols:
  • ToxicT,IrritantXi
  • Risk Codes:
  • 61-20/21/22-60
  • Safety:
  • 53-36/37/39-45-37/39-36-26 Details
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CAS No.56391-57-2 Netilmicin sulfateCompetitive Product

Netilmicin Sulfate injection

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NETILMICIN SULFATE(Bulk)

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CAS No.56391-57-2 Netilmicin sulfate

netilmicin sulfate CAS RN 56391-57-2 Molecular formula: C21H41N5O7.5/2H2SO4 Molecular weight:965.95

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Reference

Comparison of postantibiotic effects of imipenem and netilmicin alone and in combination against Pseudomonas aeruginosa
Comparison of postantibiotic effects of imipenem and netilmicin alone and in combination against Pseudomonas aeruginosa. Hostacka, Anna (Inst. Preventive Clinical Medicine, Bratislava SK-83301, Slovakia). Arzneimittel-Forschung, 47(8), 965-967 (English) 1997 Cantor. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) Imipenem (CAS 64221-86-9) as well as netilmicin (CAS 56391-57-2) at suprainhibitory concns. induced the postantibiotic effects against three P. aeruginosa strains. Imipenem (2 ′ or 4 ′ minimal inhibitory concn. (MIC)) showed postantibiotic effects in the range of 0.3-1.6 h and 0.9-4.0 h. Netilmicin at the same concns. produced postantibiotic effects of 3.0-3.8 h and 3.5-4.5 h. Postantibiotic effects manifested by imipenem (2 ′ or 4 ′ MIC) + netilmicin (2 ′ MIC) combination were somewhat longer (in the range of 4.6-4.9 h and 5.8-7.4 h) than the math. sum of postantibiotic effects induced by drugs alone (in the range of 4.1-4.7 h and 4.7-7.0 h).
Compatibility of furosemide with aminoglycoside admixtures
Compatibility of furosemide with aminoglycoside admixtures. Thompson, Dennis F.; Allen, Loyd V., Jr.; Desai, Sushama R.; Rao, Puskar S. (Dep. Pharm., State Oklahoma Teach. Hosp., Oklahoma City, OK 73126, USA). Am. J. Hosp. Pharm., 42(1), 116-19 (English) 1985. CODEN: AJHPA9. ISSN: 0002-9289. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The physicochem. interaction between furosemide (I) [54-31-9] injection 4 mL (40 mg) and admixts. of the aminoglycoside antibiotics amikacin sulfate [39831-55-5], gentamicin sulfate [1405-41-0], kanamycin sulfate [25389-94-0], netilmicin sulfate [56391-57-2], and tobramycin sulfate [49842-07-1] at 2, 1.6, 2, 1.5, and 1.6 mg/mL, resp., prepd. in 5% dextrose injection and 0.6% NaCl injection in minibags, was investigated to det. the compatibility of the drug combinations in minibags, the compatibility of 1:1 mixts. in usually administered concns., monitoring the pH changes during the administration of I to aminoglycoside soln., redissolving, purifying, and identifying the resultant ppts. I ppts. after addn. to admixts. contg. either gentamycin or netilmicin sulfates in both dextrose and NaCl injections, and therefore it is recommended that I be administered sep. or the i.v. tubing should be flushed thoroughly before and after administration of this drug via a Y-injection site.
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