Reference

The decomposition of p-aminosalicylic acid in the presence of limited amounts of water

The decomposition of p-aminosalicylic acid in the presence of limited amounts of water. Mueller, F.; Sueverkruep, R. (Pharm. Inst., Univ. Bonn, Bonn, Ger.). Pharm. Ind., 39(11), 1115-22 (German) 1977. CODEN: PHINAN. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The decarboxylation kinetics of p-aminosalicylic acid (I) [65-49-6] in the presence of limited amts. of H2O can be described satisfactorily by a nonlinear math. model which takes into account the enhancement of I soly. by m-aminophenol [591-27-5]. For H2O concns. of 23-80%, the decaroxylation began after an induction period whose length depended on the H2O content and temp., and proceeded as a first-order reaction. The rate consts. were independent of H2O concn. at a given temp.

Experimental studies on drug sensitization

Experimental studies on drug sensitization. III. Studies on the immunogenicity of some drugs and congeners of the "para" group. Cirstea, M.; Suhaciu, G.; Cirje, M. ("D. Danielopolu" Inst. Norm. Pathol. Physiol., Bucharest, Rom.). Rev. Roum. Morphol., Embryol. Physiol., Physiol., 14(4), 253-6 (English) 1977. CODEN: RMEPDZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 15 Groups of 6-8 rabbits were inoculated with sulfanilamide [63-74-1], sulfathiazole [72-14-0], sulfanilic acid [121-57-3], p-aminosalicylic acid [65-49-6], procaine [59-46-1] and p-aminobenzoic acid [150-13-0] incorporated in Freund adjuvant. Contrary to penicillin and aspirin, none of the investigated drugs and congeners gave rise to serum antibodies detectable with passive hemagglutination tests similar to those used for detecting antipenicillin and antiaspirin antibodies. The conjugates prepd. from diazotized sulfanilamide, sulfanilic acid and p-aminobenzoic acid revealed themselves highly immunogenic in rabbits, giving rise to high titers of specific antibodies against the resp. haptens. Sera contg. antihapten antibodies in high titer never agglutinated the erythrocytes incubated in solns. of the resp. drug. Thus, unlike penicillin and aspirin, none of the investigated drugs is capable of either reacting with proteins to form immunogenic conjugates in vivo, or binding to the erythrocytes rendering them agglutinable by the antibodies directed against the resp. hapten.