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CAS No.: | 5856-63-3 |
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Name: | 2-Aminobutanol |
Article Data: | 26 |
Molecular Structure: | |
Formula: | C4H11NO |
Molecular Weight: | 89.1374 |
Synonyms: | 1-Butanol,2-amino-, (-)- (7CI);1-Butanol, 2-amino-, (R)-;1-Butanol, 2-amino-, (R)-(-)-(8CI);1-Butanol, 2-amino-, l- (4CI);(-)-2-Amino-1-butanol;(2R)-2-Amino-1-butanol;(R)-(-)-2-Amino-1-butanol;(R)-(-)-2-Aminobutan-1-ol;(R)-2-Amino-1-butanol;(R)-2-Aminobutanol;D-(-)-2-Amino-1-butanol;D-2-Amino-1-butanol;[(R)-1-(Hydroxymethyl)propyl]amine; |
EINECS: | 227-476-4 |
Density: | 0.944 g/cm3 |
Melting Point: | -2 °C |
Boiling Point: | 177.2 °C at 760 mmHg |
Flash Point: | 82.2 °C |
Solubility: | Soluble in water |
Appearance: | clear colorless to light yellow viscous liquid |
Hazard Symbols: | C |
Risk Codes: | 34-37-22 |
Safety: | 26-36/37/39-45 |
Transport Information: | UN 2735 |
PSA: | 46.25000 |
LogP: | 0.41630 |
Conditions | Yield |
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61% |
2-aminobutanol
(2R)-2-aminobutan-1-ol
Conditions | Yield |
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Stage #1: 2-aminobutanol With O,O'-dibenzoyl-L-tartaric acid In acetone at 25℃; for 6h; Stage #2: With potassium hydroxide In dichloromethane | 20% |
With L-Tartaric acid |
Conditions | Yield |
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With lithium aluminium tetrahydride In tetrahydrofuran | |
With lithium aluminium tetrahydride In tetrahydrofuran | |
With sodium tetrahydroborate In tetrahydrofuran at 0 - 80℃; for 12h; Inert atmosphere; Schlenk technique; |
ethyl (2R)-2-aminobutanoate
(2R)-2-aminobutan-1-ol
Conditions | Yield |
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With lithium aluminium tetrahydride In diethyl ether |
(2R)-2-aminobutan-1-ol
Conditions | Yield |
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With perchloric acid |
(R)-(+)-2--1-butanol
(2R)-2-aminobutan-1-ol
Conditions | Yield |
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With sodium hydroxide at 80℃; for 2h; |
(R)-(+)-2-butyl acetate
(2R)-2-aminobutan-1-ol
Conditions | Yield |
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With sodium hydroxide at 80℃; for 2h; |
tert-butyl (R)-(1-hydroxybutan-2-yl)carbamate
(2R)-2-aminobutan-1-ol
Conditions | Yield |
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With methanol; Amberlyst 15; ammonia 1.) CH2Cl2, 25 deg C, 6 h, 2.) 50 min; Yield given. Multistep reaction; |
(2R)-2-aminobutan-1-ol
Conditions | Yield |
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With hydrogen; palladium on activated charcoal In methanol under 760 Torr; for 5h; |
Conditions | Yield |
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With chiral stationary phase including isopropyl-functionalized CF6 In methanol; acetic acid; triethylamine; acetonitrile at 20℃; Purification / work up; | |
With glutaraldehyde crosslinked with chitosan In water under 775.743 - 1551.49 Torr; for 10h; Inert atmosphere; Resolution of racemate; |
The (R)-(-)-2-Amino-1-butanol, with the CAS registry number 5856-63-3, is also known as 2-Amino-1-butanol, (R)-. It belongs to the product categories of Amino Alcohols (Chiral); Chiral Building Blocks; Synthetic Organic Chemistry; Amino Alcohols; Chiral Building Blocks; Organic Building Blocks. Its EINECS registry number is 227-476-4. This chemical's molecular formula is C4H11NO and molecular weight is 89.13624. Its IUPAC name is called (2R)-2-aminobutan-1-ol.
Physical properties of (R)-(-)-2-Amino-1-butanol: (1)ACD/LogP: -0.617; (2)ACD/LogD (pH 5.5): -3.70; (3)ACD/LogD (pH 7.4): -3.17; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 2; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.446; (12)Molar Refractivity: 25.609 cm3; (13)Molar Volume: 96.123 cm3 ; (14)Polarizability: 10.152 10-24cm3; (15)Surface Tension: 35.3870010375977 dyne/cm; (16)Density: 0.927 g/cm3; (17)Flash Point: 82.222 °C; (18)Enthalpy of Vaporization: 48.141 kJ/mol; (19)Boiling Point: 177.227 °C at 760 mmHg; (20)Vapour Pressure: 0.319000005722046 mmHg at 25°C
Preparation of (R)-(-)-2-Amino-1-butanol: this chemical can be prepared by 2-amino-butan-1-ol. This reaction will need reagents dibenzoyl-L-tartaric acid and aq. KOH and solvents acetone, CH2Cl2. The reaction time is 6 hours with reaction temperature of 25 °C. The yield is about 20%.
Uses of (R)-(-)-2-Amino-1-butanol: it can be used to produce (R)-2-aminobutyl-n-butyl ether. This reaction will need reagent sodium hydride. The yield is about 53%.
When you are using this chemical, please be cautious about it as the following:
This chemical may destroy living tissue on contact and may cause burns. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CCC(CO)N
(2)Isomeric SMILES: CC[C@H](CO)N
(3)InChI: InChI=1S/C4H11NO/c1-2-4(5)3-6/h4,6H,2-3,5H2,1H3/t4-/m1/s1
(4)InChIKey: JCBPETKZIGVZRE-SCSAIBSYSA-N