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CAS No.: | 66357-35-5 |
---|---|
Name: | Ranitidine hydrochloride |
Article Data: | 20 |
Molecular Structure: | |
Formula: | C13H22N4O3S |
Molecular Weight: | 314.409 |
Synonyms: | Midaven;Zenetac;1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-;Acidex; |
EINECS: | 266-332-5 |
Density: | 1.184 g/cm3 |
Melting Point: | 69-70 °C |
Boiling Point: | 437.1 °C at 760 mmHg |
Flash Point: | 218.2 °C |
Solubility: | 24.7 mg/mL in water |
Appearance: | Powder |
Safety: | 22-24/25 |
PSA: | 111.56000 |
LogP: | 2.76400 |
(E-)-N-methyl-1-(methylthio)-2-nitroethanamine
5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine
Ranitidine
Conditions | Yield |
---|---|
In water at 55℃; | 92% |
1,1-dichloro-2-nitro ethylene
2-mercaptoethylamine hydrochloride
methylamine
Ranitidine
Conditions | Yield |
---|---|
Stage #1: 1,1-dichloro-2-nitro ethylene; 2-mercaptoethylamine hydrochloride With sodium hydroxide at 50℃; for 1h; Stage #2: methylamine With calcium oxide In ethanol at 20℃; for 12h; Stage #3: 5-(N,N'-dimethylaminomethyl)-2-chloromethyl-furan In ethanol; water at 45℃; for 2h; Temperature; | 90% |
Ranitidine
Conditions | Yield |
---|---|
Stage #1: (Z)-1-β-hydroxyethylamino-1-methylamino-2-nitroethene; 5-(N,N-dimethylaminomethyl)-2-thiomethylfuran hydrobromide With hydrogenchloride at 0℃; for 40h; Stage #2: With sodium hydroxide; sodium chloride at 0℃; pH=9; | 17.3% |
nitromethane
N-methyl-N'-(2-<(5-dimethylaminomethyl)-furan-2-ylmethylthio>-ethyl)-carbodiimide
Ranitidine
Conditions | Yield |
---|---|
With sodium hydride 1.) DMF, 30 min, room temp., 2.) DMF, 90 min; Yield given. Multistep reaction; |
N,N-dimethylammonium chloride
A
Ranitidine
Conditions | Yield |
---|---|
With sodium acetate; sodium cyanoborohydride In methanol 1) -70 deg C, 3 h, 2) -18 deg C; Yield given; |
N-methyl-N'-(2-<(5-dimethylaminomethyl)-furan-2-ylmethylthio>-ethyl)-urea
Ranitidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 52 percent / (C6H5)3PBr2, (C2H5)3N / CH2Cl2 / 2 h 2: 1.) NaH / 1.) DMF, 30 min, room temp., 2.) DMF, 90 min View Scheme |
Conditions | Yield |
---|---|
With methylamine In acetonitrile |
2-(nitromethylene)thiazolidine
Ranitidine
Conditions | Yield |
---|---|
With sodium hydroxide; methylamine In water; isopropyl alcohol | |
With sodium acetate; potassium carbonate; methylamine In 4-methyl-2-pentanone; acetonitrile |
Conditions | Yield |
---|---|
With hydrogenchloride; ammonia; sodium cyanoborohydride; sodium carbonate; acetic acid; dimethyl amine In tetrahydrofuran; methanol; ethanol; water |
pyrographite
Ranitidine
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran; ethanol; water |
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Molecular structure of Ranitidine hydrochloride (CAS NO.66357-35-5) is:
Product Name: Ranitidine hydrochloride
CAS Registry Number: 66357-35-5
IUPAC Name: (E)-1-N-[2-[[5-(dimethylaminomethyl)furan-2-yl]methylsulfanyl]ethyl]-1-N'-methyl-2-nitroethene-1,1-diamine
Product Categories: Active Pharmaceutical Ingredients
Empirical Formula: C13H22N4O3S
Molecular Weight: 314.4038
EINECS: 266-332-5
Appearance: white or light yellow crystalline powder, abnormal odor, taste bitter and astringent
Index of Refraction: 1.558
Molar Refractivity: 85.64 cm3
Molar Volume: 265.4 cm3
Surface Tension: 45 dyne/cm
Density: 1.184 g/cm3
Flash Point: 218.2 °C
Enthalpy of Vaporization: 69.37 kJ/mol
Boiling Point: 437.1 °C at 760 mmHg
Melting Point: 69-70 °C
log P (octanol-water): 0.27°C
Water Solubility: 2.47E+04 mg/L at 25 °C
Vapor Pressure: 1.20E-07 mm Hg at 25 °C
InChI: InChI=1/C13H22N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3/b13-9+
Smiles: c1(oc(CSCCN\C(=C\[N+](=O)[O-])NC)cc1)CN(C)C
Ranitidine hydrochloride (CAS NO.66357-35-5) can be used as Digestive system drugs ,Potent and long-acting histamine H2 receptor antagonist.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 4286ug/kg/2D- (4.286mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | American Journal of Emergency Medicine. Vol. 17, Pg. 258, 1999. |
man | TDLo | oral | 60mg/kg/14D-I (60mg/kg) | LIVER: "JAUNDICE, CHOLESTATIC" LIVER: LIVER FUNCTION TESTS IMPAIRED SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | American Journal of Gastroenterology. Vol. 93, Pg. 822, 1998. |
mouse | LD50 | intramuscular | 280mg/kg (280mg/kg) | United States Patent Document. Vol. #4613602, | |
mouse | LD50 | intravenous | 80mg/kg (80mg/kg) | United States Patent Document. Vol. #4613602, | |
mouse | LD50 | oral | 884mg/kg (884mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 25, Pg. 749, 1990. | |
rat | LD50 | intramuscular | 2018mg/kg (2018mg/kg) | United States Patent Document. Vol. #4613602, | |
rat | LD50 | intravenous | 93mg/kg (93mg/kg) | United States Patent Document. Vol. #4613602, | |
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | United States Patent Document. Vol. #4613602, | |
women | TDLo | oral | 12mg/kg/2D-I (12mg/kg) | KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS BLOOD: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER TOPICAL EXPOSURE" | American Journal of Emergency Medicine. Vol. 12, Pg. 67, 1994. |
Safety Statements: 22-24/25
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
WGK Germany: 2
RTECS: KM6557000
Ranitidine hydrochloride (CAS NO.66357-35-5) is also called as 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro- ; MeSH Heading ; Ranitidine hydrochloride ; Ranitidine hydrochloride [USAN:INN:BAN] ; 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro- ; Achedos ; Acidex ; Atural ; Axoban ; Coralen ; Curan ; Duractin ; Ezopta ; Gastrial ; Gastrosedol ; Istomar ; Logast ; Major Ranitidine hydrochloride ; Mauran ; Microtid ; N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine ; Ptinolin ; Quantor ; Quicran ; RND ; Radinat ; Randin ; Ranidine ; Ranin ; Raniogas ; Ranisen ; Raniter ; Ranitidina ; Ranitidina [INN-Spanish] ; Ranitidinum [INN-Latin] ; Ranitiget ; Rantacid ; Ratic ; Raticina ; Sampep ; Taural ; Ul-Pep ; Ulceranin ; Urantac ; Verlost ; Vesyca ; Vizerul ; Weichilin ; Weidos ; Xanidine ; Zantab ; Zantadin .